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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (3): 106-.

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大剂量甲泼尼龙冲击治疗重症手足口病的意义

薛宁,王纪文,张洪伟   

  1. 山东大学齐鲁医院儿童医疗中心, 济南 250012
  • 收稿日期:2009-11-10 出版日期:2010-03-16 发布日期:2010-03-16
  • 通讯作者: 王纪文(1966- ),男,博士,教授,主要从事神经系统疾病研究。
  • 作者简介:薛宁(1980- ),男,硕士研究生,主要从事神经系统疾病研究。
  • 基金资助:

    山东省科技攻关计划项目(2008GGB14111)

Significance of high dose methylprednisolone in the treatment of severe handfootmouth disease

XUE Ning,  WANG Jiwen,  ZHANG Hongwei   

  1. Medical Center of Pediatrics, Qilu Hospital of Shandong University,Jinan  250012, China
  • Received:2009-11-10 Online:2010-03-16 Published:2010-03-16

摘要:

目的  探讨大剂量甲泼尼龙冲击治疗重症手足口病的疗效。方法  按是否应用大剂量甲泼尼龙冲击治疗,将重症手足口病患儿分为激素冲击组和非激素冲击组,然后对其相关临床信息进行比较分析。结果  两组患儿在发热持续时间、神经系统受累持续时间、住院时间、血压、治愈率等方面比较差异无统计学意义(P>0.05);而大剂量激素冲击组患儿的心率、呼吸频率、血糖均数明显高于非激素冲击组,差异具有统计学意义(P<0.05)。结论  大剂量激素冲击治疗重症手足口病不能缩短其病程、改善其预后;目前不支持大剂量激素冲击对重症手足口病的疗效。

关键词: 手足口病;肠道病毒71型;糖皮质激素类;临床研究

Abstract:

Objective  To discuss the therapeutic effect of high dose methylprednisolone impaction in the treatment of severe hand-foot-mouth disease.  Methods  According to whether high dose methylprednisolone was used, severe hand-foot-mouth disease cases were divided into 2 groups: the hormone impaction group and the non-hormone impaction group. Clinical information was compared and analyzed for each group. Results  The febrile duration, CNS involvement duration, time of staying in hospital, blood pressure, and recovery rate in 2 groups were not signinficantly different(P>0.05).  But, in the hormone impaction group, the heart rate, breathing rate, and serum glucose were much higher than in the non-hormone impaction group,  which demonstrated a significant difference(P<0.05). Conclusion  High dose methylprednisolone impaction in the treatment of severe hand-foot-mouth disease could not shorten the course and improves prognosis. This study did not support the efficiency of high dose methylprednisolone impaction in the treatment of severe hand-foot-mouth disease.

Key words: Hand, foot and mouth disease; Enterovirus71; Glucocorticoid; Clinical research

中图分类号: 

  • R725.1
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