利用麻醉气体监护仪床旁测定吸入麻醉药血药浓度

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (9): 86-88.

利用麻醉气体监护仪床旁测定吸入麻醉药血药浓度

吴琦，卜会敏，杜梅青，类维富

山东大学齐鲁医院麻醉科，济南 250012

收稿日期:2008-02-16 发布日期:2009-09-16
通讯作者: 类维富(1956- )，男，主任医师，主要研究计算机在麻醉中的应用。 Email:wuqimed@126.com
作者简介:吴琦(1973- )，男，主治医师，主要从事吸入麻醉药靶控麻醉的研究。Tel:13869192657

Calculating the venous blood concentration of inhalation 
anesthetics with a clinical gas analyzer

WU Qi， BU Huimin, DU Meiqing, LEI Weifu

Department of Anesthesiology, Qilu Hospital of Shandong University， Jinan 250012, China

Received:2008-02-16 Published:2009-09-16

摘要/Abstract

摘要：

目的利用麻醉气体监护仪代替气相色谱仪，结合二次平衡顶空法，建立一种床旁测定吸入麻醉药血药浓度的方法。方法首先制备安氟醚、异氟醚、七氟醚各六个浓度的标准气样，在麻醉气体分析仪的GAS SERVICE工作模式下，利用其输出端口，测量各个样本的电压峰值，得到气体浓度-电压回归方程；然后，利用与标准气样平衡的方法配置三种麻醉药的标准血样和麻醉气体监护仪，结合二次平衡法，测定血样品中吸入麻醉药回收率，每个浓度的样品均重复6次，观察此方法的精确度，即回收率的RSD。结果异氟醚、七氟醚的浓度-电压回归方程相关系数均达到0.999?9，只有安氟醚稍低，为0.999?8。分别配制与4%、2%、1%、0.5%、0.25%、0.125%气态安氟醚、异氟醚、七氟醚平衡的血液，计算其平均回收率（n=6）分别为96.53%、97.27%、97.74%。各样品六次之间回收率的RSD分别为1.63%、1.82%、1.24%。结论麻醉气体监护仪结合二次顶空法可以准确的测定血样中吸入麻醉药浓度，且不增加对血样中吸入麻醉药回收率测定的误差。

关键词: 吸入麻醉, 血药浓度, 二次平衡法

Abstract:

ObjectiveTo set up a method to measure blood concentration of inhalation anesthetics using a “headspace equilibration" method with a clinical gas analyzer during surgeries. MethodsEnflurane, isoflurane, and sevoflurane of six different concentrations were respectively prepared. Voltage peak value of each sample was determined in the mode “GAS SERVICE" of the gas analyzer. Then we got linearity between gas concentration and voltage. The standard blood samples were prepared using the “headspace equilibration" method, and retrieval rate of inhalation anesthetics in blood samples was measured using the clinical gas analyzer and the “headspace equilibration" method. Each sample was repeated six times. Precision of this method, namely relative standard deviations(RSD) was observed. ResultsThe results were well correlated with the actual concentrations of enflurane, isoflurane, and sevoflurane (r=0.999?8,0.999?9, 0.999?9). The average retrieval rate of enflurane, isoflurane, and sevoflurane was 96.53%, 97.27%, and 97.74%, and their RSD was 1.63%, 1.82%, and 1.24%, respectively. ConclusionA clinical gas analyzer can be used to exactly measure concentrations of inhalation anesthetics and not increase the error of inhalation anesthetic retrieving rate in the blood.

Key words: Anesthesia, inhalation； Plasma concentration； Doub leequilibration method

中图分类号:

R614．2

. 利用麻醉气体监护仪床旁测定吸入麻醉药血药浓度[J]. 山东大学学报(医学版), 2009, 47(9): 86-88.

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