帕金森病猫额、顶叶皮质功能改变的18FFDG PET/CT研究

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (8): 62-66.

帕金森病猫额、顶叶皮质功能改变的18FFDG PET/CT研究

侯中煜^1,2,洪淑惠³，姚树展¹，刘庆伟¹,林祥涛²,宁国庆¹,孙博²，汤煜春²,刘树伟²

1. 山东大学附属省立医院医学影像科, 济南 250021； 2. 山东大学医学院断层影像解剖学研究中心, 济南 250012；
3. 山东大学附属千佛山医院, 济南 250014

收稿日期:2008-12-12 发布日期:2009-08-16
通讯作者: 刘树伟（1962- ），男，博士，教授，主要从事断层影像解剖学、帕金森病学研究。 Email: Liusw@sdu.edu.cn
作者简介:侯中煜（1976- ），男，博士，主治医师，主要从事神经功能影像学、帕金森病学研究。

18FFDG PET/CT study on functional changes in the cortex of the frontal and parietal lobes in Prakinson′s disease

HOU Zhongyu ^1,2, HONG Shuhui ³, YAO Shuzhan ¹, LIU Qingwei ¹, LIN Xiangtao ²,
NING Guoqing ¹, SUN Bo ², TANG Yuchun², LIU Shuwei ²

1. PET/CT Research Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China;
2. Sectional and Imaging Anatomy, School of Medicine, Shandong University, Jinan 250012, China;
3. Qianfoshan Hospital, Shandong University, Jinan 250014, China

Received:2008-12-12 Published:2009-08-16

摘要/Abstract

摘要：

目的用18FFDG PET/CT技术，研究帕金森病猫模型额、顶叶皮质内脑组织糖代谢变化规律，从而证实该区域的功能变化情况，为深入的机制研究提供可靠的实验依据。方法选用健康雄性家猫，腹腔注射MPTP(5?mg/kg,qd×5?d)制作PD模型。实验共分1个对照组和4个模型组，每组4只。经行为学观察和H E染色验证后，对照组与实验组动物经静脉注射18FFDG，进行PET/CT脑断层显像，通过观察18FFDG浓聚程度确定感兴趣区（ROI），并测定该区内标准吸收值（SUV）进行半定量分析。结果PD模型首次注药后第2天时，双侧额、顶叶皮质内脑组织18FFDG浓聚程度及SUV值均保持正常（P>0.05）；第5天时双侧额叶出现明显减低（P<0.05），双侧顶叶仍保持正常；第8天时双侧额叶进一步降低（P<0.01），双侧顶叶出现明显升高（P<0.05）；第11天时双侧额叶维持在第8天时水平，双侧顶叶恢复到正常。对照组与实验组内额、顶叶皮质左、右侧相比18FFDG浓聚程度及SUV值无明显差别（P>0.05）。结论帕金森病大脑额叶皮质脑组织葡萄糖代谢降低，提示该区存在功能障碍，并随时间逐步加重，达到一定程度后趋于稳定；而顶叶皮质脑组织葡萄糖代谢升高，提示该区存在功能亢进，这可能是对额叶皮质功能低下的一种代偿，但时间短暂，呈一过性。

关键词: 帕金森病；猫；额；顶叶；体层摄影术，发射型计算机

Abstract:

To study the functional changes of the frontal and parietal cortex in cat models of Parkinson′s disease (PD). MethodsHealthy male cats were injected MPTP to establish animal models of diplPD. The four model groups comprised by 2, 5, 8 and 11 days after the first drug pour. After observation of biological behavior and HE stain, model groups were injected with 18FFDG i.v. Then, we determined the region of interest (ROI) by observing 18FFDG intensity and carried out a semiquantitative analysis after detecting the standard absorption value (SUV) in this area. ResultsCompared with the control group, the 18FFDG intensity and SUV were normal in both sides of the frontal and parietal cortex in the PD models on the 2nd day after the first injection（P>0.05）, and was significantly reduced on the 5th day in both sides of the frontal cortex（P<0.05）, but remained normal in both sides of the parietal cortex. The value of both sides of the frontal cortex on the 8th day was lower than that on the 5th day, while both sides of the parietal cortex significantly increased compared with that on the 5th day(P<0.05). On the 11th day, the value ofboth sides of the frontal cortex was consistent with that on the 8th day, while the value of both sides of the parietal cortex returned to the normal level on the 8th day. There was no difference between the left and right sides of the frontal and parietal cortex of each group(P>0.05). ConclusionsReduction of glucose metabolism in the frontal cortex of PD suggests that there is a functional disorder in this area, aggravating with time and being stable at some degree, while the increase of glucose metabolism in the parietal cortex of PD suggests that there is a transient functional accentuation in this area as a compensation for dysfunction of the frontal cortex.

Key words: Parkinson disease; Cats; Forehead; Parietal lobe; Tomograpny, ernissioncomputed

中图分类号:

R742

. 帕金森病猫额、顶叶皮质功能改变的18FFDG PET/CT研究[J]. 山东大学学报(医学版), 2009, 47(8): 62-66.

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