脑神康对糖尿病大鼠脑内单胺类神经递质含量的影响

山东大学学报(医学版)

脑神康对糖尿病大鼠脑内单胺类神经递质含量的影响

耿磊¹，刘德山¹，郝媛媛¹，郭瑞臣¹，王新陆²，张维东³

1. 山东大学齐鲁医院门诊部，济南 250012； 2. 山东中医药大学，济南 250011；3. 山东省医学科学院基础医学研究所，济南 250062

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-07-16 发布日期:2008-07-16
通讯作者: 刘德山

Effect of the Naoshenkang on monoamine neurotransmitters in the brain tissue of diabetes mellitus rats

GENG Lei¹, LIU De-shan¹, HAO Yuan-yuan¹, GUO Rui-chen¹, WANG Xin-lu², ZHANG Wei-dong³

1. Department of Outpatient, Qilu Hospital of Shandong University, J
inan 250012, China;2. Shandong University of Traditional Chinese Medicine, Jinan 250011, China;3. Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China

Received:1900-01-01 Revised:1900-01-01 Online:2008-07-16 Published:2008-07-16
Contact: LIU De-shan

摘要/Abstract

摘要： 目的〓〖HTK〗观察益气补肾中药对糖尿病大鼠脑内单胺类神经递质含量的影响。〖HTW〗方法〓〖HTK〗腹腔注射链脲佐菌素（STZ）建立糖尿病Wistar大鼠模型，随机分为模型对照组和脑神康组，健康大鼠为正常对照。脑神康组每日给予脑神康，按600mg/kg灌
胃，其他两组给予等量生理盐水灌胃，喂养6周后处死动物，采静脉血测血糖、胰岛素，取脑
组织检测脑内单胺类神经递质含量。〖HTW〗结果〓〖HTK〗脑神康组的血糖、胰岛素水平
均低于模型对照组（P均＜0.05），大脑组织中的去甲肾上腺素（NE）、多巴胺（DA）显著降低，5-羟色胺（5-HT）显著升高，与糖尿病对照组比较差异均有统计学意义（P＜0.05）。〖HTW〗结论〓〖HTK〗益气补肾中药能有效调节糖尿病大鼠脑内单胺类神经递质含量。

关键词: 近交系, 单胺类神经递质, 大鼠, 糖尿病, 脑神康

Abstract:

Objective〓〖WTBZ〗To explore the effect of the traditional Chinese medicine, Naoshenkang on monoamine neurotransmitters in brain tissues of diabetes mellitus rats. 〖WTHZ〗Methods〓〖WTBZ〗The diabetic model of Wistar rats was duplicated with one streptozotocin intraperitoneal injection, and then the model were randomly divided into 2 groups: the model control group and the Naoshenkang-treatment group, and healthy rats served as the normal control group. The Naoshenkang-treatment group was lavaged with 600?mg/kg naoshenkang per day, and the model control and the normal control groups were given an equal dose of normal saline. On the sixth weekend, all rats were killed， and then levels of blood sugar and insulin were determined, also the monoamine neurotransmitters in the discrete brain areas were determined. 〖WTHZ〗Results〓〖WTBZ〗The levels of blood sugar and insulin of the Naoshenkang-treatmentgroup were significantly lower than those of the model group(P＜0.05), also the levels of
norepinephrine (NE) and dopamine (DA) were decreased while the level of 5-hydroxytryptamine (5-HT) was significantly increased in the Naoshenkang-treatment group. The level of monoamine neurotransmitters was significantly different between the Naoshenkang-treatment group and the model group(P＜0.05). 〖WTHZ〗Conclusion〓〖WTBZ〗The traditional Chinese medicine Naoshenkang can efficiently regulate the level of monoamine neurotransmitters in brain tissues of diabetes mellitus rats.

Key words: Naoshenkang, Diabetes mellitus, Monoamine neurotransmitter, Rats, inbred strains

中图分类号:

R587.1

耿磊,刘德山,郝媛媛,郭瑞臣,王新陆,张维东 . 脑神康对糖尿病大鼠脑内单胺类神经递质含量的影响[J]. 山东大学学报(医学版), 2008, 46(7): 689-692.

GENG Lei,LIU De-shan,HAO Yuan-yuan,GUO Rui-chen,WANG Xin-lu,ZHANG Wei-dong. Effect of the Naoshenkang on monoamine neurotransmitters in the brain tissue of diabetes mellitus rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(7): 689-692.

参考文献

相关文章 15

[1]	吴逸南葛志明李方贺红姜虹张运. 自发性高血压大鼠肾脏血管紧张素转换酶2的表达[J]. 山东大学学报(医学版), 2209, 47(6): 5-.
[2]	祝林胡三元张光永丁祥就. 前列腺素E2对阻塞性黄疸大鼠小肠粘膜形态的保护作用[J]. 山东大学学报(医学版), 2209, 47(6): 12-.
[3]	孙涛张道来谢珊珊王玉卓冯玉新辛华. 酒精对原代培养的神经前体细胞间隙连接蛋白43表达的影响[J]. 山东大学学报(医学版), 2209, 47(6): 20-.
[4]	张道来孙涛谢珊珊王玉卓赵玲冯玉新辛华. 体外原代培养胎鼠大脑皮层神经元NMDAR1亚基表达的发育性变化[J]. 山东大学学报(医学版), 2209, 47(6): 28-32.
[5]	孔令群,王学文,王海滨,曹学峰,吴燕彬,张兴元. 副神经节瘤1例报告[J]. 山东大学学报 (医学版), 2020, 1(9): 110-112.
[6]	张宝文,雷香丽,李瑾娜,罗湘俊,邹容. miR-21-5p靶向调控TIMP3抑制2型糖尿病肾病小鼠肾脏系膜细胞增殖及细胞外基质堆积[J]. 山东大学学报 (医学版), 2020, 1(7): 7-14.
[7]	张亮,徐敏,庄向华,娄福臣,娄能俊,吕丽,郭文娟,郑凤杰,陈诗鸿. 内质网应激与凋亡在糖尿病周围神经病变中的表达变化[J]. 山东大学学报（医学版）, 2017, 55(8): 13-17.
[8]	刘芳,乔蕾,陈文超,杨丽娜. 大蒜素后处理对大鼠心肌缺血-再灌注损伤的保护作用[J]. 山东大学学报（医学版）, 2017, 55(7): 6-11.
[9]	张振堂,杨洋,韩福俊,陈向华,季晓康,王永超,王淑康,孙苑潆,李敏,陈亚飞,王丽,薛付忠,刘言训. 基于社区2型糖尿病患者的心脑血管事件5年风险预测模型[J]. 山东大学学报（医学版）, 2017, 55(6): 108-113.
[10]	苏萍,杨亚超,杨洋,季加东,阿力木·达依木,李敏,薛付忠,刘言训. 健康管理人群2型糖尿病发病风险预测模型[J]. 山东大学学报（医学版）, 2017, 55(6): 82-86.
[11]	李帅,王雅琳,孙忠文,朱梅佳. Nod样受体蛋白3炎性体在2型糖尿病脑微血管内皮细胞中的变化及变化机制[J]. 山东大学学报（医学版）, 2017, 55(3): 6-11.
[12]	谢海滨,武群政,刘少壮,黄鑫,程玉刚,胡三元,张光永. 肝线粒体相关内质网膜在袖状胃切除术改善糖尿病大鼠胰岛素敏感性中的作用[J]. 山东大学学报（医学版）, 2017, 55(10): 36-40.
[13]	巩璐伟,周丽珍,苏国海. 培哚普利通过调节Akt-FoxO1通路保护糖尿病性心肌病大鼠心功能损伤[J]. 山东大学学报（医学版）, 2017, 55(10): 65-70.
[14]	杨洋,张光,张成琪,宋心红,薛付忠,王萍,王丽,刘言训. 基于体检队列的2型糖尿病风险预测模型[J]. 山东大学学报（医学版）, 2016, 54(9): 69-72.
[15]	彭力,强晔,赵蕙琛,陈诗鸿,姚伟东,刘元涛. 2型糖尿病患者应用西格列汀的短期疗效及影响因素[J]. 山东大学学报（医学版）, 2016, 54(8): 60-63.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed