大蒜素对糖尿病高半胱氨酸血症大鼠脑干听觉诱发电位的影响

山东大学学报(医学版)

大蒜素对糖尿病高半胱氨酸血症大鼠脑干听觉诱发电位的影响

郝媛媛¹，刘德山¹，李伟¹，王新陆²，周密³，王竹梅³

1. 山东大学齐鲁医院中医科，济南 250012； 2. 山东中医药大学，济南 250011；3. 山东中医药大学附属医院特检科，济南 250012

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-07-16 发布日期:2008-07-16
通讯作者: 刘德山

Effect of allicin on brainstem auditory evoked potential in diabetes mellitus rats with homocysteine

HAO Yuan-yuan¹,　LIU De-shan¹, LI Wei¹, WANG Xin-lu², ZHOU Mi³, WANG Zhu-mei³

1. Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Shandong University of Traditional Chinese Medicine, Jinan 250011, China;3. Department of Test, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250012, China

Received:1900-01-01 Revised:1900-01-01 Online:2008-07-16 Published:2008-07-16
Contact: LIU De-shan

摘要/Abstract

摘要：

目的〓〖HTK〗观察大蒜素对糖尿病高半胱氨酸(Hcy)血症大鼠脑干听觉诱发电位的影响。〖HTW〗方法〓〖HTK〗从60只Wistar大鼠中随机抽取10只作为正常对照组，余下50只腹腔注射链脲佐菌素（STZ）造成糖尿病模型，取其中40只随机分为空白对照组、模型对照组、叶酸-VitB6组、大蒜素治疗组，每组10只。模型对照组、叶酸-VitB6组、大蒜素治疗组均给予高蛋氨酸饲料，制备糖尿病高Hcy血症模型；大蒜素治疗组每日给大蒜素8mg/kg腹腔注射；叶酸-VitB6组给予叶酸、维生素B6、维生素B12灌胃；喂养6周检测脑干听觉诱发电位(BAEP)后处死动物，采静脉血测血糖、Hcy水平。〖HTW〗结果〓〖HTK〗大蒜素治疗组的血糖、Hcy水平低于模型对照组（P均<0.01），且Hcy水平与正常对照组比较差异无统计学意义（P>0.05）；大蒜素治疗组大鼠的BAEP各波峰潜伏期（PL）与正常对照组接近，且Ⅰ～Ⅲ波峰间潜伏期(IPL)和Ⅰ～Ⅴ IPL较空白对照组、模型对照组明显缩短差异具有统计学意义（P均<0.05）。〖HTW〗结论〓〖HTK〗大蒜素能有效治疗糖尿病高Hcy血症，改善糖尿病脑神经损害。

关键词: 听觉, 脑干, 高半胱氨酸, 诱发电位, 糖尿病, 大鼠, 近交系, 大蒜素

Abstract:

Objective〓〖WTBZ〗To explore the effects of allicin on brainstem auditory evoked potential(BAEP) in diabetes mellitus rats with homocysteine. 〖WTHZ〗Methods〓〖WTBZ〗10 of 60 male Wistar rats were randomly used as the normal control group and the rest were injected with STZ into the peritoneal. Then 40 of 50 rats were randomly divided into 4 groups: the blank control group, the model control group, the western medicine treatment group and the allicin treatment group. The last three groups were fledged with homomethionin animal feed for six weeks to make the model of diabetes mellitus with homocysteine. The allicin group was subjected to peritoneal injection with 8mg/kg allicin. The western medicine group was givenfolacin, Vit B6 and VitB 12. On the sixth weekend, the BAEP was examined and the insulin and Hcy levels were determined. [WTHZ]Results〓〖WTBZ〗The insulin and Hcy levels of the allicin treatment group were obviously lower than those of the model control group(P<0.01）, and the level of Hcy was similar to those of the normal control groups（P>0.05）. The peak latency（PL）of all waves in the allicin treatment group was similar to that of the normal control group, but the inter-peak latency (IPL) of the Ⅰ-Ⅲ orⅠ-Ⅴ waves was obviously shorter than that of the blank control group and the model group （P<0.05）. 〖WTHZ〗Conclusion〓〖WTBZ〗Allicin is effective in restoring the injured cerebral function of diabetes mellitus rats with homocysteine.

Key words: Allicin, Diabetes mellitus, Homocysteine, Evoked potentials, auditory, brain stem, Rat, inbred strains

中图分类号:

R587.1

郝媛媛,刘德山,李伟,王新陆,周密,王竹梅 . 大蒜素对糖尿病高半胱氨酸血症大鼠脑干听觉诱发电位的影响[J]. 山东大学学报(医学版), 2008, 46(7): 685-688.

HAO Yuan-yuan,LIU De-shan,LI Wei,WANG Xin-lu,ZHOU Mi,WANG Zhu-mei

. Effect of allicin on brainstem auditory evoked potential in diabetes mellitus rats with homocysteine[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(7): 685-688.

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