47例HBeAg阴性慢性乙型肝炎拉米夫定停药后疗效持久性研究

山东大学学报(医学版)

47例HBeAg阴性慢性乙型肝炎拉米夫定停药后疗效持久性研究

李晓迎，王磊，刘峰

山东大学医学院济南市传染病医院，山东济南 250021

收稿日期:2006-12-10 修回日期:1900-01-01 出版日期:2007-09-24 发布日期:2007-09-24
通讯作者: 王磊

Durability of the effects after cessation of lamivudine for 47 patients with HBeAg-negative chronic hepatitis B

LI Xiao-ying, WANG Lei, LIU Feng

Jinan Infectious Disease Hospital, School of Medicine, Shandong University,Jinan 250021, Shandong, China

Received:2006-12-10 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
Contact: WANG Lei

摘要/Abstract

摘要： 研究HBeAg阴性慢性乙型肝炎(HBeAg阴性慢乙肝)停药后拉米夫定疗效的持久性及影响因素。方法：对47例使用拉米夫定总疗程≥24月、HBV-DNA阴转达18个月以上HBeAg阴性慢乙肝，分别于停药后进行肝脏生化学、HBV-DNA检测和随访观察。结果：停药后3、6、12、24和36个月累计复发率分别为25.5%、25.5%、41.8%、48.3%和54.8%。复发23例，在4、9和12个月的复发累计病例分别占复发病例的52.2%、65.2%和82.6%，复发最长的1例为39个月。停药时的年龄与拉米夫定停药后疗效持久性有关。结论：HBeAg阴性慢乙肝拉米夫定停药后疗效持久性较HBeAg阳性低，年龄轻者复发率低。

Abstract: Objective: To investigate the durability of the effects after cessation of lamivudine for HBeAg-negative chronic hepatitis B(CHB) patients. Methods: Forty-seven patients subjecting to lamivudine for no less than 24 months and their HBVDNA-negative duration more than 18 months were enrolled in this study. Hepatic biochemical parameters, HBV-DNA determination, and follow-up were determined after cessation of lamivudine. Results: The cumulative rate of relapse after 3, 6, 12, 24 and 36 months after cessation of lamivudine was 25.5%, 25.5%, 41.8%, 48.3% and 54.8%, respectively. Twenty-three patients relapsed and the latest happened on the 39th month. The cumulative relapse ratio at month 4, 9 and 12 was 52.2%. 65.2% and 82.6%, respectively. The durability of the effects after cessation of lamivudine was related to age at the end of treatment. Conclusion: Durability of the effects after cessation of lamivudine of HBeAg-negative patients is lower than that of HBeAg-positive ones. The younger the patient is, the lower the relapse rate.

Key words: Chronic hepatitis B, Lamivudine, Durability, Effectiveness

中图分类号:

R575.1

李晓迎,王磊,刘峰. 47例HBeAg阴性慢性乙型肝炎拉米夫定停药后疗效持久性研究[J]. 山东大学学报(医学版), 2007, 45(9): 938-939.

LI Xiao-ying,WANG Lei,LIU Feng. Durability of the effects after cessation of lamivudine for 47 patients with HBeAg-negative chronic hepatitis B[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(9): 938-939.

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