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山东大学学报 (医学版) ›› 2025, Vol. 63 ›› Issue (12): 79-95.doi: 10.6040/j.issn.1671-7554.0.2025.0159

• 临床医学 • 上一篇    

基于SS-OCTA探讨眼轴对全周脉络膜厚度及血流密度的影响

刘雪芬1,2,3,4,杨儒1,2,3,王淑霞1,2,3,郝海涛1,2,3,梁璐1,2,3,刘畅5,龚蕤1,2,姜双1,2,3   

  1. 1.锦州医科大学第三临床医学院, 辽宁 锦州 121001;2.锦州医科大学附属第三医院眼科, 辽宁 锦州 121002;3.锦州医科大学儿童青少年健康促进协同创新中心, 辽宁 锦州 121001;4.广州卫生职业技术学院临床医学院, 广东 广州 510500;5. 锦州市中心医院眼科, 辽宁 锦州 121000
  • 发布日期:2025-12-19
  • 通讯作者: 龚蕤. E-mail:ruigongc@163.com
  • 基金资助:
    辽宁省科技厅第二批揭榜挂帅项目(2022JH1/10800071);辽宁省教育厅科研平台建设项目(LJ232410160047);辽宁省教育厅高等学校基本科研项目(LJKFZ20220248)

Impact of axial length on circumferential choroidal thickness and vessel density using SS-OCTA

LIU Xuefen1,2,3,4, YANG Ru1,2,3, WANG Shuxia1,2,3, HAO Haitao1,2,3, LIANG Lu1,2,3, LIU Chang5, GONG Rui1,2, JIANG Shuang1,2,3   

  1. 1. The Third of Clinical Medical, Jinzhou Medical University, Jinzhou 121001, Liaoning, China;
    2. Department of Ophthalmology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou 121002, Liaoning, China;
    3. Collaborative Innovation Center for Children and Adolescents Health Promotion, Jinzhou Medical University, Jinzhou 121001, Liaoning, China;
    4. Department of Clinical Medical, Guangzhou Health Science College, Guangzhou 510500, Guangdong, China;
    5. Department of Ophthalmology, Jinzhou Central Hospital, Jinzhou 121000, Liaoning, China
  • Published:2025-12-19

摘要: 目的 比较不同眼轴的全周24 mm×20 mm范围3×3网格中9个区域的脉络膜厚度(choroidal thickness, ChT)及血流密度的差异,探讨眼轴长度(axial length, AL)对全周脉络膜厚度及血流的影响。 方法 横断面研究,选取新疆裕民小中高6~18岁儿童青少年843人,按照AL分 4 组: 短眼轴组,≤22 mm(112眼); 正常眼轴组,22 mm26 mm(153眼)。采用超广域SS-OCTA 测量全周24 mm×20 mm范围的脉络膜指标,包括ChT、脉络膜毛细血管血流密度(choroidal capillary perfusion, CCP)、脉络膜血管指数(choroidal vascular index, CVI)、脉络膜血管体积比(choroidal vascular volume ratio, CVV)、脉络膜基质指数(choroidal stromal index, CSI)、脉络膜基质体积比(choroidal stroma volume ratio, CSV),按区域划分为颞上、上方、鼻上、颞侧、黄斑中央区、鼻侧、颞下、下方、及鼻下等9个区域,对比4组各项指标各区域的差异以及与AL的相关性。 结果 4组颞上、上方、鼻上、颞侧、黄斑中央区、鼻侧、颞下、下方和鼻下等9个区域(全周24 mm×20 mm)的ChT、CVI、CVV和CSV呈显著差异,并随着AL的增加而下降,相反各区域CSI随眼轴的增长而增加(P<0.001),除上方区域的CCP存在显著差异外(P=0.006),其他8个区域的CCP无明显差异(P>0.001)。两两比较显示:在长眼轴组中,9个区域的ChT、CVV均低于短眼轴组、正常眼轴组和较长眼轴组(P均<0.001);9个区域的CSI均高于短眼轴组、正常眼轴组、较长眼轴组(P均<0.001);长眼轴组9个区域的CVI、CSV均低于短眼轴组、正常眼轴组;此外,9个区域的ChT、CVV、CVI、CSV均与眼轴呈负相关(P<0.001),CSI的9个区域和上方区域的CCP与眼轴呈正相关(P<0.001),其中黄斑中央区ChT相关性最强(rs=-0.597, P<0.001),上方区域CCP相关性最弱(rs=1.70, P<0.001)。 结论 随着AL增加,ChT变薄存在区域差异,且在黄斑区最为明显;脉络膜血流密度降低也存在区域差异,周边部降低最为明显。同时黄斑中央区ChT可能有望作为近视进展的早期预警或近视筛查的指标之一。

关键词: SS-OCTA, 眼轴, 脉络膜厚度, 脉络膜血流

中图分类号: 

  • R773.4
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