您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (4): 12-16.doi: 10.6040/j.issn.1671-7554.0.2020.376

• • 上一篇    

济南市新型冠状病毒肺炎密切接触者隔离医学观察情况分析与评价

杨丽,李战,刘晓雪,焦海涛,周林,刘庆皆,刘铁诚,耿兴义   

  1. 济南市疾病预防控制中心, 山东 济南 250021
  • 发布日期:2022-09-27
  • 通讯作者: 耿兴义. E-mail:gengxingyi@163.com

Analysis and evaluation of the isolation medicine observation for close contacts of New Coronavirus Pneumonia in Jinan City

YANG Li, LI Zhan, LIU Xiaoxue, JIAO Haitao, ZHOU Lin, LIU Qingjie, LIU Tiecheng, GENG Xingyi   

  1. Jinan Municipal Center for Disease Control and Prevention, Jinan 250021, Shandong, China
  • Published:2022-09-27

摘要: 目的 分析济南市新型冠状病毒肺炎(NCP)密切接触者隔离医学观察情况。 方法 收集2020年1月24日至3月1日济南市NCP处置期间流行病学调查资料,筛选出因新型冠状病毒(COVID-19)被隔离的密切接触者信息,采用Excel 2007和SPSS16.0软件对数据资料进行整理与分析。 结果 共对1 455例NCP密切接触者进行隔离医学观察,从中共检出28例COVID-19感染者,包括25例确诊NCP病例和3例阳性无症状者,罹患率为1.92%。1 455例NCP密切接触者主要分布在历下区(40.69%)、历城区(16.98%)及市中区(8.38%)。与原发病例不同关系的密切接触者的COVID-19检出率不同(χ2=180.34, P<0.001),其中与原发病例为亲属关系的密切接触者罹患率最高(15.38%)。COVID-19感染的密切接触者共有13例原发病例,其中5例(38.46%)有武汉旅行史,1例(7.69%)有湖北旅行史,3例(23.08%)有除湖北外外地旅行史,其余4例(30.77%)无外地旅行史。济南市管理的密切接触者中23例发病,其中8例(34.78%)在密切观察期前已发病,发病至隔离的时间间隔中位数为5 d。15例(65.22%)在隔离观察期内发病,时间间隔中位数为3 d。23例NCP密切接触者医学观察期至确诊时间中位数2 d,发病至确诊时间中位数为3 d。济南市管理的密切接触者中23例发病,其中17例(73.91%)临床严重程度为普通型患者,6例(23.09%)为轻型患者。 结论 NCP病例密切接触者中存在阳性无症状者;应针对重点地区输入人员及密切接触者进行筛查,尽早采取综合防控措施;加强高危人群居家隔离的个人防护措施。

关键词: 新型冠状病毒肺炎, 密切接触者, 隔离医学观察, 罹患率, 效果评价

Abstract: Objective To analyze the isolation medicine observation for close contacts of New Coronavirus Pneumonia(NCP)in Jinan City. Methods All information of close contacts who were isolated due to COVID-19 was collected from the epidemiological survey during the epidemic of COVID-19 in Jinan City from January 24 to March 1, 2020. The softwares of Excel 2016 and SPSS16.0 were used to sort and analyze data. Results A total of 1 455 close contacts were isolated for medical observation. A total of 28 cases of COVID-19 infection were detected, including 25 cases of confirmed NCP and 3 cases of positive asymptomatic. The attack rate was 1.92%. 1 455 close contacts were mainly distributed in Lixia District(40.69%), Licheng District(16.98%)and Shizhong District(8.38%). The detection rate of COVID-19 was different among close contacts who had a different relationship with the primary case(χ2=180.34, P<0.001), among which close-connected cases had the highest incidence of close contacts(15.38%). There were 13 primary cases of close contacts of COVID-19 infection, of which 5(38.46%)had a travel history in Wuhan City, 1(7.69%)had a travel history in Hubei province, and 3(23.08%)had traveled outside Hubei Province, the remaining 4 cases(30.77%)had no history of field travel. There were 23 of the close contacts who were managed by Jinan City developed disease, of which 8(34.78%)had developed disease before the close observation period, and the median time interval from onset to isolation was 5 days. There were 15 patients(65.22%)who developed disease during the isolation observation period with a median interval of 3 days. The median time of 23 close contacts from the beginning of the medical observation period to the diagnosis was 2 days, and the median time from onset to diagnosis was 3 days. There were 23 of the close contacts who were managed by Jinan City developed disease, of which 17 patients(73.91%)was ordinary type, and 6 patients(23.09%)were mild. Conclusion There are positive and asymptomatic persons in close contact with COVID-19 infection cases. Screening should be conducted for imported personnel and close contacts who come from key areas. Comprehensive prevention and control measures should be taken as soon as possible. Personal protection measures for home isolation of high-risk groups should be strengthened.

Key words: New coronavirus pneumonia, Close contacts, Isolated medical observation, Attack rate, Effect evaluation

中图分类号: 

  • R181.3
[1] 中国疾病预防控制中心新型冠状病毒肺炎疫情防控技术组. 新型冠状病毒肺炎流行病学特征分析[J]. 中华流行病学杂志, 2020,41(2):145-151. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases(COVID-19)in China[J]. Chinese Journal of Epidemiology, 2020, 41(2): 145-151.
[2] 武汉市卫生健康委员会. 武汉市卫健委关于当前我市肺炎疫情的情况通报[EB/OL]. [2019-12-31] http://wjw.wuhan.gov.cn/front/web/showDetail/201912310-8989.
[3] Sohrabi C, Alsafi Z, ONeill N, et al. World Health Organization declares Global Emergency: A review of the 2019 Novel Coronavirus(COVID-19)[J]. Int J Surg, 2020, doi:76:71-76. doi:10.1016/j.ijsu.2020.02.034.
[4] 中华人民共和国国家卫生健康委员会. 新型冠状病毒肺炎诊疗方案(试行第7版)[EB/OL].[2020-03-04] http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9-294a7dfe4cef80dc7f5912eb1989.shtml.
[5] 中华人民共和国国家卫生健康委员会. 新型冠状病毒肺炎防控方案(第5版)[EB/OL].[2020-02-21] http://www.nhc.gov.cn/jkj/s3577/202002/a5d6f7b8c48c451c-87dba14889b30147.shtml.
[6] Qing GQ, Yang NB, Ding F, et al. Epidemiologic and clinical characteristics of 91 hospitalized patients with COVID-19 in Zhejiang, China: a retrospective, multi-centre case series[J]. QJM, 2020.17. doi:10.1093/ajmed/hcaa089.
[7] 卫生应急办公室. 截至3月1日24时新型冠状病毒肺炎疫情最新情况[EB/OL]. [2020/03/10]. http://www.nhc.gov.cn/xcs/yqtb/202003/5819f3e13ff6413ba-05fdb45b55b66ba.shtml.
[8] 山东省卫生健康委员会. 山东省新型冠状病毒肺炎疫情情况[EB/OL]. [2020-03-02] http://wsjkw.shandong.gov.cn/ztzl/rdzt/qlzhfkgz/tzgg/202003/t20200302_259-5393.html.
[9] 高文静, 李立明. 新型冠状病毒肺炎潜伏期或隐性感染者传播研究进展[J]. 中华流行病学杂志, 2020,41(4):485-488. GAO Wenjing, LI Liming. Advances on presymptomatic or asymptomatic carrier transmission of COVID-19[J]. Chinese Journal of Epidemiology, 2020, 41(4): 485-488.
[10] 李士雪, 单莹. 新型冠状病毒肺炎研究进展述评[J]. 山东大学学报(医学版), 2020,58(3):19-25. LI Shixue, SHAN Ying. Latest research advances on novel coronavirus pneumonia [J]. Journal of Shandong University(Health Sciences), 2020, 58(3): 19-25.
[11] 周生余, 王春婷, 张伟, 等. 山东省新型冠状病毒肺炎患者537 例临床特征与救治效果[J]. 山东大学学报(医学版), 2020, 58(3): 44-51. ZHOU Shengyu, WANG Chunting, ZHANG Wei, et al. Clinical characteristics and treatment effect of 537 cases of novel coronavirus pneumonia in Shandong Province[J]. Journal of Shandong University(Health Sciences), 2020, 58(3): 44-51
[12] 山东省人民政府. 山东省启动重大突发公共卫生事件Ⅰ级响应[EB/OL]. [2020-01-24] http://www.jinan.gov.cn/art/2020/1/25/art_1862_3880794.html.
[13] Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients[J]. N Engl J Med, 2020, 382(12): 1177-1179.
[14] BAI Yan, YAO Lingsheng, WEI Tao, et al. Presumed Asymptomatic Carrier Transmission of COVID-19[J]. JAMA, 2020. doi:10.1001/jama.2020.2565.
[15] 李佳萌, 易群,魏茂刚,等. 1例新型冠状病毒肺炎二代患者及其密切接触者的管理探索[J]. 解放军医学院学报, 2020:41:1-5.
[16] 中国疾病预防控制中心新型冠状病毒肺炎疫情防控技术组. 新型冠状病毒肺炎流行病学特征的最新认识[J]. 中华流行病学杂志, 2020,41(2):139-144. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. An update on the epidemiological characteristics of novel coronavirus diseases(COVID-19)[J]. Chinese Journal of Epidemiology, 2020,41(2):139-144.
[17] 胡世雄, 徐巧华, 罗恺伟, 等. 湖南省新型冠状病毒肺炎感染者流行病学特征分析[J]. 实用预防医学, 2020,27:1-4. HU Shixiong, XU Qiaohua, LUO Kaiwei, et al. Epidemiological characteristics of patients with coronavirus disease 2019 in Hunan province[J]. Practical Preventive Medicine, 2020, 27:1-4.
[18] Hu Z, Song C, Xu C, et al. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China[J]. Sci China Life Sci, 2020,4. doi:10.1007/s11427-020-1661-4.
[19] 崔亮亮, 耿兴义, 赵小冬, 等. 济南市现阶段新型冠状病毒肺炎的流行特征与思考[J]. 山东大学(医学版), 2020,58(3):52-57. CUI Liangliang, GENG Xingyi, ZHAO Xiaodong, et al. Reflection and epidemiological characteristics of coronavirus disease 2019 in Jinan City[J]. Journal of Shandong University(Health Sciences), 2020, 58(3): 52-57.
[20] 袁婧, 孙艳雨, 左玉洁, 等. 重庆市223例新型冠状病毒肺炎患者的临床特征分析[J]. 西南大学学报(自然科学版), 2020,42(3):1-7.
[1] 曹义海. 血管生成在疾病治疗中的应用与展望[J]. 山东大学学报 (医学版), 2021, 59(9): 9-14.
[2] 杨璇,李岩志,马伟,贾崇奇. 基于两样本孟德尔随机化的肺功能与新型冠状病毒肺炎病死风险的因果关系[J]. 山东大学学报 (医学版), 2021, 59(7): 104-111.
[3] 周溪,黄霂晗,任玉洁,邱洋. 新型冠状病毒感染与天然免疫及炎症反应[J]. 山东大学学报 (医学版), 2021, 59(5): 15-21.
[4] 于莹,张功,刘晶,颜世童,韩涛,黄海量. 基于网络药理学和分子对接方法探析黄芪预防新型冠状病毒肺炎的潜在作用机制[J]. 山东大学学报 (医学版), 2021, 59(4): 6-16.
[5] 任敏敏,王广梅,张丽,杨瑶瑶,封丹珺. 335名抗疫一线护理人员心理弹性对共情疲劳的影响[J]. 山东大学学报 (医学版), 2021, 59(2): 88-94.
[6] 袁勇贵,李磊,沈仲夏,陈刚,吴义高,岳莹莹. 新型冠状病毒肺炎疫情下精神障碍诊疗的防控策略[J]. 山东大学学报 (医学版), 2020, 58(4): 1-6.
[7] 常彩云,于秋燕,赵小冬,王芳,李伟,阮师漫,耿兴义. 济南市首例新型冠状病毒肺炎病例及其相关家庭聚集性疫情分析[J]. 山东大学学报 (医学版), 2020, 58(4): 7-11.
[8] 山东大学齐鲁医院新型冠状病毒肺炎诊治专家组. 新型冠状病毒肺炎疑似病例诊断及管理专家共识·齐鲁医院标准[J]. 山东大学学报 (医学版), 2020, 58(3): 1-7.
[9] 山东大学齐鲁医院新型冠状病毒肺炎防控工作组. 山东大学齐鲁医院新型冠状病毒肺炎防控策略与实践[J]. 山东大学学报 (医学版), 2020, 58(3): 8-18.
[10] 李士雪,单莹. 新型冠状病毒肺炎研究进展述评[J]. 山东大学学报 (医学版), 2020, 58(3): 19-25.
[11] 鞠秀丽. 间充质干细胞治疗新型冠状病毒肺炎的潜在机制和研究进展[J]. 山东大学学报 (医学版), 2020, 58(3): 32-37.
[12] 周生余,王春亭,张伟,王锡明,董亮. 山东省新型冠状病毒肺炎患者537例临床特征与救治效果[J]. 山东大学学报 (医学版), 2020, 58(3): 44-51.
[13] 崔亮亮,耿兴义,赵小冬,杨国樑,常彩云,赵梦娇,李战,王春荣,刘岚铮,阮师漫. 济南市现阶段新型冠状病毒肺炎的流行特征与思考[J]. 山东大学学报 (医学版), 2020, 58(3): 52-57.
[14] 张孝国,马艳,肖嘉安,张忠法. 济南市儿童新型冠状病毒肺炎的临床特征[J]. 山东大学学报 (医学版), 2020, 58(3): 62-64.
[15] 余雪源,张硕,燕芳芳,苏德振. 采用清肺排毒汤联合西药43例与单用西药46例的新型冠状病毒肺炎临床疗效比较[J]. 山东大学学报 (医学版), 2020, 58(12): 47-53.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!