足月新生儿大脑皮质时间-空间异质性发育的磁共振弥散张量及弥散峰度

doi:10.6040/j.issn.1671-7554.0.2019.594

摘要/Abstract

摘要： 目的通过绘制足月新生儿大脑皮质磁共振弥散张量(DTI)与弥散峰度(DKI)参数随孕龄的变化,探讨大脑皮质的时间-空间异质性发育。方法获取胎龄为36.6至44.4孕周正常新生儿颅脑的T₁加权图像(T₁WI)及多球壳弥散数据。并采用皮质骨架(GBSS)算法分别测量并计算额叶、顶叶、枕叶、颞叶皮质的弥散参数,包括各向异性分数(FA)、平均弥散率(MD)、轴向弥散值(AD)、径向弥散值(RD)及平均弥散峰度(MK)等弥散参数值。结果 40孕周前,大脑皮质的FA及AD值下降,差异均有统计学意义(额叶AD:β=-0.49,P=0.01;顶叶FA:β=-0.48,P=0.02;顶叶AD:β=-0.62,P=0.003;颞叶FA:β=-0.44,P=0.04;颞叶AD:β=-0.5,P=0.01;枕叶FA:β=-0.53,P=0.01;枕叶AD:β=-0.55,P=0.009)。40孕周后大脑皮质的弥散参数差异均无统计学意义(P>0.05);额叶的发育速率快于枕叶(F=9.36,P=0.004);MK值变化观察补充了大脑皮质微结构变化的信息。结论新生儿大脑皮质各个脑叶DTI及DKI参数在时间维度、空间维度变化速率的差异性反映了大脑皮质时间-空间异质性发育的规律。

关键词: 新生儿, 大脑皮质, 时间-空间异质性发育, 多球壳弥散图像

Abstract: Objective To explore the spatio-temporal development of newborn cerebral cortex by describing the changes of parameters from diffusion tensor image(DTI)and diffusion kurtosis image(DKI)with newborns with different gestational ages. Methods The T₁WI and multiple-shell DWI data of brain of newborn with gestational age ranging from 36.6 to 44.4 weeks were obtained. The diffusion parameters including fractional anisotraphy(FA), mean diffusivity(MD), axial diffusivity(AD), radial diffusivity(RD)and mean kurtosis(MK)were analyzed with GBSS method. Results Dramatic decrease of FA and AD values were detected from cerebral cortex before 40 gestational weeks(frontal lobe AD: β=-0.49, P=0.01; parietal lobe FA: β=-0.48, P=0.02; parietal lobe AD: β=-0.62, P=0.003; temporal lobe FA: β=-0.44, P=0.04; temporal lobe AD: β=-0.5, P=0.01; occipital lobe FA: β=-0.53, P=0.01; occipital lobe AD: β=-0.55, P=0.009), while no significant result was found within any lobe after 40 PCW. The frontal lobe had higher developmental rate than the occipital lobe(F=9.36, P=0.004). The changes of MK values supplemented the information of cerebral cortex microstructure changes. Conclusion The differences among changes of parameters from DTI and DKI data in the time and spatial dimensions reflect the spatio-temporal development of cerebral cortex 山东大学学报 (医学版)57卷9期 -王丽凤,等.足月新生儿大脑皮质时间-空间异质性发育的磁共振弥散张量及弥散峰度 \=-of newborn.

Key words: Newborn, Cerebral cortex, Spatial-temporal development, Diffusion image of multi-spherical shell

中图分类号:

R742.8

王丽凤,李峥,于乔文. 足月新生儿大脑皮质时间-空间异质性发育的磁共振弥散张量及弥散峰度[J]. 山东大学学报 (医学版), 2019, 57(9): 97-103.

WANG Lifeng, LI Zheng, YÜ Qiaowen. MR-diffusion tensor image and diffusion kurtosis image of spatio-temporal development of new-born cerebral cortex[J]. Journal of Shandong University (Health Sciences), 2019, 57(9): 97-103.

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