“良性淋巴瘤”概念的提出及其存在的可能性

doi:10.6040/j.issn.1671-7554.0.2016.1083

摘要/Abstract

摘要： 淋巴瘤是一种来源于淋巴造血系统的肿瘤,按照以往的观点,淋巴瘤是一种单克隆增生的淋巴组织恶性肿瘤,没有“良性淋巴瘤”概念。近年来在淋巴瘤临床诊治实践中新发现一些生物学行为偏良性的单克隆增生淋巴组织病变,病变恶性潜能极其有限,几乎无进展,对传统淋巴瘤概念和诊断标准形成了一个挑战,也产生了一些疑问和困惑。基于此,作者在国内首次提出了“良性淋巴瘤”的观点并探讨其存在的可能性,期望以此引发专家们对淋巴瘤生物学本质问题的共同探讨和思考。

关键词: 淋巴瘤, 生物学本质, 克隆性, 良性淋巴瘤

Abstract: Lymphoma is a kind of tumor that comes from lymphatic hematopoietic. According to the previous points of views, lymphoma is a kind of malignant tumor which proliferates monoclonally. The concept of “benign lymphoma” does not exist at present. In the clinical practice of recent years, we have found that some monoclonal lymphoid tissue lesions show benign biological behavior and their malignant potential is extremely limited and almost does not develop, so it presents a challenge to the concept of lymphoma and its diagnostic standard. Based on this, the author proposes the concept of “benign lymphoma” here for the first time in China, and discusses the possibility of its existence, so as to 山东大学学报 (医学版)55卷3期 -李文生.“良性淋巴瘤”概念的提出及其存在的可能性 \=-trigger the discussion on the biological essence of lymphoma.

Key words: Benign lymphoma, Clonality, Lymphoma, Biological essence

中图分类号:

R733.4

李文生. “良性淋巴瘤”概念的提出及其存在的可能性[J]. 山东大学学报（医学版）, 2017, 55(3): 1-5.

LI Wensheng. Presentation of the concept of “benign lymphoma” and the discussion of the possibility of its existence[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 1-5.

参考文献

[1] 陈万清, 张思维, 郑荣寿, 等.中国2009年恶性肿瘤发病和死亡分析[J].中国肿瘤, 2013,22(1): 2-12. CHEN Wanqing, ZHANG Siwei, ZHENG Rongshou, et al. Report of cancer incidence and mortality in China, 2009[J]. China Cancer, 2013, 22(1): 2-12.
[2] Townsend DE, Sparkes RS, Baluda MC, et al. Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis by glucose-6-phosphate dehydrogenase[J].Am J Obstet Gynecol, 1970, 107(8): 1168-1173.
[3] Apel RL, Ezzat S, Bapat BV, et al. Clonality of thyroid nodule in sporadic goiter[J]. Diagn Mol Pathol, 1995, 4(2):113-121.
[4] Namba H, Matsuo K, Fagin JA. Clonal composition of benign and malignant human thyroid tumors[J]. J Clin Invest, 1990, 86(1):120-125.
[5] 韦萍,周小鸽,王翠芝. 基因重排检测在恶性淋巴瘤诊断中的应用[J]. 临床和实验医学杂志,2005,4(4):233-236. WEI Ping, ZHOU Xiaoge, WANG Cuizhi. Gene rearrangement detection in the diagnosis of malignant lymphoma[J]. Journal of Clinical and Experimental Medicine, 2005, 4(4): 233-236.
[6] Chen YL, Su IJ, Cheng HY, et al. BIOMED-2 protocols to detect clonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell lymphomas in southern Taiwan[J]. Leuk Lymphoma, 2010, 51(4): 650-655.
[7] Böer A, Tirumalae R, Bresch M, et al. Pseudoclonality in cutaneous pseudolymphomas: a pitfall in interpretation of rearrangement studies[J]. Br J Dermatol, 2008, 159(2): 394-402.
[8] Marti GE, Rawstron AC, Ghia P, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis[J]. Br J Haematol, 2005, 130(3): 325-332.
[9] Shimanovsky A, Alvarez Argote J, Murali S, et al. Autoimmune manifestations in patients with multiple myeloma and monoclonal gammopathy of undetermined significance[J]. BBA Clin, 2016, 6: 12-18. doi: 10.1016/j.bbacli.2016.05.004.
[10] Swick BL, Baum CL, Venkat AP, et al. Indolent CD8+ lymphoid proliferation of the ear: report of two cases and review of the literature[J]. J Cutan Pathol, 2011, 38(2): 209-215.
[11] 周小鸽,张燕林,谢建兰,等.对EB病毒相关淋巴增殖性疾病的理解和认识[J].中华病理学杂志,2016, 45(12):1-6. ZHOU Xiaoge, ZHANG Yanlin, XIE Jianlan, et al. The understanding of Epstein-Barr virus associated lymphoproliferative disorder[J]. Chin Pathol, 2016, 45(12): 1-6
[12] Banerjee DD. Recent advances in the pathobiology of Hodgkins lymphoma: potential impact on diagnostic, predictive, and therapeutic strategies[J]. Adv Hematol. 2011: 439456. doi: 10.1155/2011/439456.
[13] Villegas Gracia R, Franco Alzate C, Rendón Henao J, et al. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia[J]. Colomb Med(Cali), 2016, 47(2): 81-86.
[14] Scarfò L, Ghia P. What does it mean I have a monoclonal B-cell lymphocytosis? Recent insights and new challenges[J]. Semin Oncol, 2016, 43(2): 201-208.
[15] Marti GE, Shim YK, Albitar M, et al. Long-term follow-up of monoclonal B-cell lymphocytosis detected in environmental health studies[J]. Cytometry B Clin Cytom, 2010, 78(Suppl 1): S83-90.
[16] Moy BT, Wilmot J, Ballesteros E, et al. Primary follicular lymphoma of the gastrointestinal tract: case report and review[J]. J Gastrointest Cancer, 2016, 47(3): 255-263.
[17] Graham RL, Mardones MA, Krause JR. Primary follicular lymphoma of the duodenum[J]. Proc(Bayl Univ Med Cent), 2015, 28(3): 381-383.
[18] Louissaint A Jr, Schafernak KT, Geyer JT, et al. Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations[J]. Blood, 2016, 128(8): 1093-1100.
[19] Louissaint A Jr, Ackerman AM, Dias-Santagata D, et al. Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement[J]. Blood, 2012, 120(12): 2395-2404.
[20] 李小秋. 淋巴瘤病理研究新进展[J]. 中国癌症杂志,2014,24(10):721-726. LI Xiaoqiu. New advances in lymphoma pathology[J]. China Oncology, 2014,24(10):721-726.
[21] Zhang X, Zheng Y, Xie J, et al. Long-term tumor-free survival with untreated primary diffuse large B-cell lymphoma of the Tonsil: a report of 9 cases[J]. Am J Surg Pathol, 2015, 39(11): 1493-1501.
[22] Geyer JT, Ferry JA, Harris NL, et al. Florid reactive lymphoid hyperplasia of the lower female genital tract(lymphoma-like lesion): a benign condition that frequently harbors clonal immunoglobulin heavy chain gene rearrangements[J]. Am J Surg Pathol, 2010, 34(2): 161-168.
[23] Mojtahed A, Pai RK, Anderson MW, et al. Reactive lymphoid hyperplasia of the terminal ileum: a benign(lymphoma-like)condition that may harbor aberrant immunohistochemical patterns or clonal immunoglobulin heavy chain gene rearrangements[J]. Appl Immunohistochem Mol Morphol, 2014, 22(8): 585-592.
[24] Bermudez G, González de Villambrosía S, Martínez-López A, et al. Incidental and isolated follicular lymphoma in situ and mantle cell lymphoma in situ lack clinical significance[J]. Am J Surg Pathol, 2016, 40(7): 943-949.
[25] James E, Sokhn JG, Gibson JF, et al. CD4+ primary cutaneous small/medium-sized pleomorphic T-cell lymphoma: a retrospective case series and review of literature[J]. Leuk Lymphoma, 2015, 56(4): 951-957.
[26] 易树华,邹德慧, Ken He Young,等. 2016版WHO淋巴肿瘤分类修订解读[J]. 中华医学杂志, 2016, 96(42): 3365-3369. YI Shuhua, ZOU Dehui, Ken He Young, et al. Decipher the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Natl Med J China, 2016, 96(42): 3365-3369.
[27] Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms[J]. Blood, 2016, 127(20):2375-2390.

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