大蒜油在小鼠体内抗流感病毒作用

doi:10.6040/j.issn.1671-7554.0.2015.746

山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (7): 23-27.doi: 10.6040/j.issn.1671-7554.0.2015.746

大蒜油在小鼠体内抗流感病毒作用

郑倩倩¹,刘倜²,谢克勤³,林艺²,李忠²,王显军²,毕振强²,温红玲³,宋艳艳³,赵丽³

1.天津市滨海新区塘沽疾病预防控制中心检验科, 天津 300450;2.山东省疾病预防控制中心, 山东济南 250014;3. 山东大学公共卫生学院, 山东济南 250012

收稿日期:2015-08-07 出版日期:2016-07-10 发布日期:2016-07-10
通讯作者: 赵丽. E-mail:dlzhl@sdu.edu.cn E-mail:dlzhl@sdu.edu.cn
基金资助:
山东省科技计划项目(2009GG10002054)

Anti-influenza virus activities of garlic oil in mice model in vivo

ZHENG Qianqian¹, LIU Ti², XIE Keqin³, LIN Yi², LI Zhong², WANG Xianjun², BI Zhenqiang², WEN Hongling³, SONG Yanyan³, ZHAO Li³

1. Clinical Laboratory of Tanggu Center for Disease Control and Prevention, Tianjin 300450, China;
2. Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China;
3. School of Public Health, Shandong University, Jinan 250012, Shandong, China

Received:2015-08-07 Online:2016-07-10 Published:2016-07-10

摘要/Abstract

摘要： 目的探讨大蒜油在小鼠体内抗流感病毒的作用。方法小鼠经口给予低、中、高3个剂量［25、50、100 mg/(kg·d)］的大蒜油,之后接种流感病毒,分别为低、中、高剂量大蒜油组;同时设空白对照组、病毒对照组、溶剂对照组和阳性药对照组。观察大蒜油对小鼠流感模型的一般活动状态、体质量、肺脏、死亡率和平均存活时间的影响。结果与病毒对照组相比,低、中、高剂量大蒜油组和阳性药对照组的小鼠一般状态较好,体质量增加,肺部病变较轻,死亡率较低;与溶剂对照组比较,低、中、高剂量大蒜油组和阳性药对照组的小鼠平均存活时间较长(P<0.05)。结论大蒜油在小鼠体内有一定抗流感病毒作用。

关键词: 流感病毒, 体内, 大蒜油, 小鼠模型

Abstract: Objective To investigate the effect of garlic oil on anti-influenza virus in mice in vivo. Methods The mice were given low, medium and high doses of garlic oil［25、50、100 mg/(kg·d)］ through the mouths, and divived into low, medium and high dose of garlic oil groups,then the flu virus was vaccinated. Meanwhile, the blank, virus, solvent and positive drug control groups were set up. Active state, body weight, lung, mortality and average survival time of mice were observed. Results Compared with the virus control group, the mice in the low, medium and high dose of garlic oil groups and positive drug control group had better states, higher body weights, less lung indexes, more relieved lung lesions and lower death rates; compared with the solvent control group, the survival time extended in the low, medium and high dose of garlic oil groups and positive drug control group(P<0.05). Conclusion Garlic oil has the anti-influenza virus activities to some degree in mice model in vivo.

Key words: Influenza virus, In vivo, Mice model, Garlic oil

中图分类号:

R373.1

郑倩倩,刘倜,谢克勤,林艺,李忠,王显军,毕振强,温红玲,宋艳艳,赵丽. 大蒜油在小鼠体内抗流感病毒作用[J]. 山东大学学报（医学版）, 2016, 54(7): 23-27.

ZHENG Qianqian, LIU Ti, XIE Keqin, LIN Yi, LI Zhong, WANG Xianjun, BI Zhenqiang, WEN Hongling, SONG Yanyan, ZHAO Li. Anti-influenza virus activities of garlic oil in mice model in vivo[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 23-27.

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大蒜油在小鼠体内抗流感病毒作用

Anti-influenza virus activities of garlic oil in mice model in vivo

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