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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (9): 77-80.doi: 10.6040/j.issn.1671-7554.0.2014.400

• 临床医学 • 上一篇    下一篇

乳腺癌患者血浆D-二聚体水平与预后关系的探讨

李玲1, 王丽丽2, 王胜江2, 于超2, 刘延鹏2, 徐成伟2   

  1. 1. 山东省肿瘤医院外科, 山东 济南 250117;
    2. 山东大学第二医院检验科, 山东 济南 250033
  • 收稿日期:2014-06-16 修回日期:2014-09-04 出版日期:2014-09-10 发布日期:2014-09-10
  • 基金资助:
    济南市高校自主创新计划(201303048)

Research on the relationship between plasma D-dimer level and prognosis of breast cancer

LI Ling1, WANG Lili2, WANG Shengjiang2, YU Chao2, LIU Yanpeng2, XU Chengwei2   

  1. 1. Department of Surgery, Shandong Provincial Tumor Hospital, Jinan 250117, Shandong, China;
    2. Department of Laboratory Medicine, Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2014-06-16 Revised:2014-09-04 Online:2014-09-10 Published:2014-09-10
  • Contact: 徐成伟。E-mail:xuchengwei-jyk@163.com E-mail:xuchengwei-jyk@163.com

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摘要： 目的 分析乳腺癌患者血浆D-二聚体水平的变化，探讨其与乳腺癌患者预后的关系。方法 收集原发性乳腺癌患者92例（病例组）和健康体检者85例（正常对照组），采用胶乳增强免疫比浊法测定血浆中D-二聚体水平，同时采用免疫组化法检测ER、PR、HER2、Ki-67和P53的表达；随访8个月，观察患者生存情况。分析根据不同指标分组的乳腺癌患者血浆D-二聚体水平的变化。结果 病例组与正常对照组相比血浆D-二聚体水平显著升高（P<0.01）；随访期间生存者血浆D-二聚体水平显著低于死亡者（P<0.05）；不同ER、PR、HER2、Ki-67和P53表达的乳腺癌患者间血浆D-二聚体水平无明显差异（P>0.05）。结论 D-二聚体可作为评价乳腺癌预后的指标，能够预测乳腺癌患者生存状况，而与激素受体等免疫组化指标无关。

关键词: 乳腺癌, 预后, 免疫组化, D-二聚体

Abstract: Objective To analyze the changes of plasma D-dimer level in breast cancer patients, and to investigate the relationship between the level of D-dimer and prognosis of breast cancer. Methods A total of 92 cases of primary breast cancer and 85 healthy controls were enrolled. The level of D-dimer was measured with latex-enhanced immunoassay, and ER, PR, HER2, Ki-67 and P53 levels were detected with immunohistochemical methods. During the follow-up of 8 months, the plasma D-dimer levels in breast cancer patients were analyzed. Results The level of D-dimer in breast cancer patients was significantly higher compared to that of the healthy controls (P<0.01); the level of D-dimer in survivors during follow-up was significantly lower than that in those who died (P<0.05); the level of plasma D-dimer in breast cancer patients with different expressions of ER, PR, HER2, Ki-67 and P53 showed no significant difference (P>0.05). Conclusion D-dimer can act as a predictor of breast cancer prognosis, while it has nothing to do with other immunohistochemical indexes.

Key words: Breast cancer, D-dimer, Prognosis, Immunohistochemistry

中图分类号: 

  • R737.9
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