子痫前期患者远期预后及其后代发病风险的评估

doi:10.6040/j.issn.1671-7554.0.2017.861

摘要/Abstract

摘要： 目的探讨子痫前期患者远期预后及其后代妊娠时子痫前期发病风险。方法选择在临邑县人民医院健康体检部、济南市妇幼保健院查体中心、山东大学齐鲁医院健康体检中心查体有子痫前期病史的患者311例为研究组;选择同年龄组正常妊娠分娩的328例女性作为对照组,两组人群妊娠前均无高血压、糖尿病、肾脏疾病、心脑血管疾病及其他内科合并症病史。采用χ2检验比较两组人群发生高血压、心脑血管疾病等并发症,以及两组人群的女儿妊娠时罹患子痫前期情况。结果〓研究组患者发生高血压(23.79% vs 8.23%, P<0.001)、糖尿病(11.25% vs 6.71%, P=0.044)、微蛋白尿(21.54% vs 6.10%, P<0.001)、慢性肾脏病(10.29% vs 5.79%, P=0.036)、心力衰竭(2.57% vs 0.61%, P=0.046)及脑卒中(3.22% vs 0.91%, P=0.039)的概率均高于对照组,两组各远期预后指标比较差异均有统计学意义(P<0.05)。研究组患者的女儿妊娠时子痫前期发病率较无子痫前期家族史者明显升高(OR:5.35; 95%CI:2.20~12.97)。结论子痫前期患者远期发生心脑血管疾病的风险增加,其后代妊娠时发生子痫前期的风险也增加。

关键词: 子痫前期, 远期预后, 后代, 家族史, 复发, 防控

Abstract: Objective To investigate the long-term prognosis of women who suffered preeclampsia and the risk of preeclampsia in their female offspring. Methods A total of 311 women with a history of preeclampsia were recruited as the observation group, while 328 women with normal delivery were enrolled as the control group. Both groups satisfied the following criteria: no history of hypertention, diabetes, renal diseases, cardiovascular and brain diseases, or other medical complications before pregnancy. The occurrence of hypertension, cardiovascular diseases and preeclampsia during pregnancy in the female offspring of these subjects were analyzed with χ2 test. Results The incidence of hypertension(23.79% vs 8.23%, P<0.001), diabetes(11.25% vs 6.71%, P=0.044), microalbuminuria(21.54% vs 6.10%, P<0.001), chronic kidney disease(10.29% vs 5.79%, P=0.036), heart failure(2.57% vs 0.61%, P=0.046), and stroke(3.22% vs 0.91%, P=0.039)were higher in the observation group than those in the control group. Long-term prognosis figures showed that the differences between the two groups were statistically significant(P<0.05). The incidence of preeclampsia in the female offspring of women with history of preeclampsia was significantly higher than those without history of preeclampsia (OR: 5.35; 95% CI: 2.20~12.97). Conclusion Preeclampsia is a risk factor for long-term cardiovascular disease. The female offspring of women with history of preeclampsia have increased risks of preeclampsia during pregnancy. For women with family history of preeclampsia, prenatal checkup should be strength- 山东大学学报 (医学版)55卷12期 -王润梅,等. 子痫前期患者远期预后及其后代发病风险的评估 \=-ened and prevention measures should be taken early enough so as to improve the long-term prognosis.

Key words: Preeclampsia, Long-term prognosis, Offspring, Family history, Recurrence, Prevention and control

中图分类号:

R714.25

王润梅,杨秋红,张芳,马玉燕. 子痫前期患者远期预后及其后代发病风险的评估[J]. 山东大学学报 (医学版), 2017, 55(12): 31-35.

WANG Runmei, YANG Qiuhong, ZHANG Fang, MA Yuyan. Long-term prognosis of women preeclampsia and risks of incidence in their female offspring[J]. Journal of Shandong University (Health Sciences), 2017, 55(12): 31-35.

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