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山东大学学报 (医学版) ›› 2026, Vol. 64 ›› Issue (8): 96-106.doi: 10.6040/j.issn.1671-7554.0.2026.0717

• 临床医学 • 上一篇    

血清尿酸与儿童青少年代谢综合征的关联:基于山东、河北两省的横断面研究

冯建1,杨丽2,王永俊3,刘长青4,田美娜4,周晗5,于连龙6   

  1. 1.山东大学齐鲁医院营养科, 山东 济南 250012;2.济南市疾病预防控制中心传染病防治所, 山东 济南 250021;3.山东第一医科大学第一附属医院(山东省千佛山医院)营养科, 山东 济南 250014;4.河北省疾病预防控制中心营养与食品安全所, 河北 石家庄 050021;5.山东省疾病预防控制中心食品与营养所, 山东 济南 250014;6.山东省疾病预防控制中心公共卫生监测评价所, 山东 济南 250014
  • 发布日期:2026-08-14
  • 通讯作者: 于连龙. E-mail:lianlong00a@163.com
  • 基金资助:
    山东省医药卫生科技项目(202512031110)

Association between serum uric acid and metabolic syndrome in children and adolescents: a cross-sectional study in Shandong and Hebei provinces, China

FENG Jian1, YANG Li2, WANG Yongjun3, LIU Changqing4, TIAN Meina4, ZHOU Han5, YU Lianlong5   

  1. 1. Department of Clinical Nutrition, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Department of Infectious Disease Prevention and Control, Jinan Municipal Center for Disease Control and Prevention, Jinan 250021, Shandong, China;
    3. Department of Clinical Nutrition, The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Jinan 250014, Shandong, China;
    4. Institute of Nutrition and Food Safety, Hebei Center for Disease Control and Prevention, Shijiazhuang 050021, Hebei, China;
    5. Institute of Food and Nutrition, Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China;
    6. Institute of Public Health Monitoring and Evaluation, Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China
  • Published:2026-08-14

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摘要： 目的 探讨10~14岁儿童青少年血清尿酸水平与代谢综合征的关联,分析血清尿酸在该年龄段人群代谢综合征分层筛查中的潜在临界参考值,为儿童青少年代谢综合征的早期筛查、风险分层及精准防控提供流行病学参考依据。 方法 选取2016—2017年中国营养与健康调查中山东、河北两省3 098名10~14岁儿童青少年为研究对象,收集人口学特征、生活方式、体格测量及实验室检测指标。采用多因素logistic回归分析血清尿酸与代谢综合征及其各组分的独立关联;运用限制性立方样条模型分析二者剂量-反应关系;通过ROC曲线确定血清尿酸判别代谢综合征的最佳临界值。 结果 研究人群代谢综合征患病率为3.87%;校正多项混杂因素后,血清尿酸与代谢综合征及腹型肥胖、高血压、血脂紊乱等各组分均呈独立正相关(P<0.001)。限制性立方样条分析显示,血清尿酸浓度与代谢综合征患病风险呈线性正相关。血清尿酸预测10~14岁儿童青少年代谢综合征的最佳临界值为334.5 μmol/L。 结论 本研究基于山东、河北两省10~14岁儿童青少年样本开展分析,发现血清尿酸与该年龄段人群代谢综合征存在独立关联;334.5 μmol/L可作为鲁冀两省该年龄段群体代谢综合征筛查分层的参考界值之一,上述发现可为该区域儿童青少年的健康管理与代谢性疾病防控提供初步参考。

关键词: 儿童青少年, 代谢综合征, 血清尿酸, 剂量反应关系, 临界值

Abstract: Objective To investigate the association between serum uric acid(SUA)and metabolic syndrome(MetS)in children and adolescents aged 10-14 years, and to determine an optimal SUA cut-off for stratified screening, with the goal of providing epidemiological evidence for early detection, risk stratification, and precision prevention in this population. Methods Data were derived from the 2016-2017 Chinese National Nutrition and Health Survey(CNHS). A total of 3,098 participants aged 10-14 years were enrolled from Shandong and Hebei provinces. Demographic characteristics, lifestyle factors, anthropometric measurements, and laboratory parameters were collected. Multivariate logistic regression was used to examine the independent associations of SUA with MetS and its individual components. Restricted cubic spline(RCS)analysis was employed to evaluate the dose-response relationship, and receiver operating characteristic(ROC)curve analysis was performed to identify the optimal SUA cut-off for predicting MetS. Results The overall prevalence of MetS in the study population was 3.87%. After adjusting for multiple confounders, SUA was independently and positively correlated with MetS and each of its components, including abdominal obesity, hypertension, and dyslipidaemia(P<0.001). RCS analysis revealed a progressive increase in MetS risk with rising SUA levels. The optimal SUA cut-off value for predicting MetS was determined to be 334.5 μmol/L. Conclusion Our findings demonstrate an independent association between SUA and MetS among children and adolescents aged 10-14 years in Shandong and Hebei provinces. The identified cut-off of 334.5 μmol/L may serve as a reference threshold for stratified screening in this regional population, offering preliminary evidence to support health management and metabolic disease prevention efforts in this area.

Key words: Children and adolescents, Metabolic syndrome, Serum uric acid, Dose-response relationship, Cut-off value

中图分类号: 

  • R58
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