JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Heterozygosity loss at FHIT, SLIT2 and EDNRB gene in endometrical carcinoma

XIE Min1，WEI De-e1，WANG Bo2，LU Ai-ying1   

  1. 1.Department of Gynecology and Obsterics, Jinan Central Hospital, Jinan 250013; 2.Department of Gynecology and Obsterics, Qilu Hospital of Shandong University, Jinan 250012
  • Received:2006-09-29 Revised:1900-01-01 Online:2007-01-24 Published:2007-01-24
  • Contact: XIE　Min

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Abstract: Objective：To study the loss of heterozygosity(LOH) at FHIT, SLIT2 and EDNRB gene at microsatellite markers D3S1287, D4S1593, and D13S160 in endometrial carcinoma. Methods： Tumor tissues and relatively normal tissues of thirty-five cases of endometrial carcinoma were examined by using PCR-denaturing PAGE-silver staining at microsatellite markers D3S1287, D4S1593, and D13S160. Results： The total LOH rate was 54.3%, and LOH rate of D3S1287, D4S1593, and D13S160 was 34.5%, 20.5%, and 19.3%, respectively. The LOH rate at FHIT, SLIT2, and EDNRB gene did not positively correlate with the stage of clinical-pathogensis in endometrial carcinoma. Conclusion： LOH exists at micro-satellite markers of FHIT, SLIT2, and EDNRB gene in endometrial carcinoma, suggesting that FHIT, SLIT2, and EDNRB gene are tumor suppressor genes(TSGs) and the inactivity of TSGs maybe one of the reasons for carcinoma.

Key words: Endometrial neoplasms, Gene, FHIT, Gene, SLIT2, Gene, EDNRB, Loss of heterozygosity

CLC Number: 

  • R737.33
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