JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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〖KH+9.2mmD]Proliferation of endometrial stromal cells in endometriosis induced by Interleukin1beta

ZHANG Gui-yu, REN Shu-wen,ZHANG You-zhong,MA Dao-Xin   

  1. 1. Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012,Shandong, China; 2. The 8th People′s Hospital of Qingdao, Qingdao 266000, Shandong, China;
  • Received:2005-10-29 Revised:1900-01-01 Online:2006-09-24 Published:2006-09-24

Abstract: To investigate the proliferation of endometrial stromal cells in endometriosis by interleukin1beta(IL1β). Methods: The eurotopic endometrial stromal cells of endometriosis cultured within 3～5 passages were treated with IL1β in a dosage of 0 to 10.0?ng/ml, and then the cell proliferation and the cell cycle were measured by MTT and flow cytometry (FCM) respectively. Results: The endometrial stromal cells had been growing luxuriantly, and G0/G1 phase cells were few than G2/M and S phase cells. Moreover, the proliferation was the most prominent when the cells were incubated in the presence of IL1β at 1.0?ng/ml concentration for 12 hours. Conclusions: IL1β induces the proliferation of endometrial stromal cells of endometriosis and promotes the transformation of G0/G1 phase cells into G2/M and S phase.

Key words: Endometriosis, Interleukin1, Cell cycle

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