JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Identification of glyguanid, phenformin, gliclazide and glyburide addedinto traditional Chinese medicine for antidiabetes

LI Bing,WANG Ben-jie,HUANG Ping,WEI Chun-min,GUO Rui-chen   

  1. 1. Shandong Institute of Drug Control, Jinan 250012, Shandong, China; 2.Institute of Clinical Pharmacology,Qilu Hospital of Shandong Univewrsity, Jinan 250012, Shandong, China
  • Received:2006-03-29 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24

Abstract: To identify glyguanid, phenformin,gliclazide and glyburide added into traditional Chinese medicine for antidiabetes. Methods: The HPLC and LC/MS methods were established and used to quantitatively identify the components of traditional Chinese medicines, Tangleshu and Ketangmin capsules on the basis of retention time, chemical structure and molecular weight. Results: Phenformin and glyburide were found in Tangleshu capsule, glyguanid and gliclazide were found in Ketangmin capsule. Conclusion: HPLC and LC/MS methods can be used to quantitatively determine the four above mentioned components simultaneously.

Key words: Hypoglycemic agents, Medicine, Chinese Traditional, Glyguanid, Phenformin, Gliclazide, Glyburide, Chromatography

[1] CHEN Wanyu, HUANG Lili, BIAN Hongsheng, WANG Yanyan, YU Shuang, JIN Yang. Research progress on traditional Chinese medicine regulating PI3K/AKT pathway to improve sleep disorders and cognitive impairments [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 8-18.
[2] HAN Shuang, TIAN Xiaowei, ZHANG Xinyu, KONG Yang. Research on the optimization of the “Sports-medicine-nursing care integration” policy in Shandong Province from the perspective of policy tools [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 116-124.
[3] HU Chengyang, JI Hongli, LIU Weijing. Empirical research of narrative medicine education from a phenomenological perspective: a combined survey report on medical students cognitive level and competence of narrative medicine [J]. Journal of Shandong University (Health Sciences), 2025, 63(10): 107-116.
[4] YU Zhigang, ZHENG Chao. Current status, challenges and innovative approaches of multidisciplinary treatment for breast cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(1): 1-9.
[5] ZHANG Jintao, DONG Liang. Airway epithelium and epithelial-derived cytokines in asthma: reflection and outlook [J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 1-6.
[6] SUN Xiao, MA Chuanwei, ZHAO Min, XI Bo. Current status and influencing factors of professional cognition and identity among preventive medicine undergraduates [J]. Journal of Shandong University (Health Sciences), 2024, 62(12): 109-116.
[7] HUANG Juan, WANG Yinglin, LI Jiaxin, LIU Ronghang, ZHANG Xifa, LI Min, CHEN Wei, QIU Miao, HAN Chunlei. Survey on the current situation, influencing factors and pathways of knowledge, attitude and practice related to traditional Chinese medicine among residents of 16 cities in Shandong Province [J]. Journal of Shandong University (Health Sciences), 2024, 62(11): 115-124.
[8] YU Danfeng, CAO Juan, YU Shijia, DU Lutao, HOU Xinguo. Diagnostic capacity of electrochemiluminescence immunoassay compared with liquid chromatography-tandem mass spectrometry for vitamin D deficiency in diabetic patients [J]. Journal of Shandong University (Health Sciences), 2023, 61(7): 90-95.
[9] Andong GUO,Sentai DING. Progress in the establishment and application of organoids of bladder cancer [J]. Journal of Shandong University (Health Sciences), 2023, 61(11): 20-26.
[10] SUN Jiye, WANG Ziou, SUN Xiaowei, LI Hongtao. Effects of traditional Chinese medicine fumigation combined with extracorporeal shock wave therapy on 72 cases of femoroacetabular impingement syndrome and serum inflammatory factor [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 76-81.
[11] HAN Xuan, SUN Xiubin, LIU Yi, WANG Shukang, LIU Jing, YUAN Zhongshang, ZHANG Tao, LI Xiujun, XUE Fuzhong, LIU Yunxia. Evaluation of learning satisfaction of preventive medicine students with Health Statistics [J]. Journal of Shandong University (Health Sciences), 2022, 60(3): 109-113.
[12] WANG Chuanxin. Liquid biopsy of tumor [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 64-71.
[13] YANG Jun. Medico-engineering cooperation: a strategic plateau of neurosurgery innovation and development in the era of precision medicine [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 83-88.
[14] WANG Linlin, SUN Yuping. From the perspective of clinicians: the application and reflection of artificial intelligence in cancer precision diagnosis and treatment [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 89-96.
[15] LIU Dongke, WANG Fengshan. Identification of heparin and heparan sulfate by HILIC-MS/MS [J]. Journal of Shandong University (Health Sciences), 2021, 59(3): 41-47.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd