JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Identification of glyguanid, phenformin, gliclazide and glyburide addedinto traditional Chinese medicine for antidiabetes

LI Bing,WANG Ben-jie,HUANG Ping,WEI Chun-min,GUO Rui-chen   

  1. 1. Shandong Institute of Drug Control, Jinan 250012, Shandong, China; 2.Institute of Clinical Pharmacology,Qilu Hospital of Shandong Univewrsity, Jinan 250012, Shandong, China
  • Received:2006-03-29 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24

Abstract: To identify glyguanid, phenformin,gliclazide and glyburide added into traditional Chinese medicine for antidiabetes. Methods: The HPLC and LC/MS methods were established and used to quantitatively identify the components of traditional Chinese medicines, Tangleshu and Ketangmin capsules on the basis of retention time, chemical structure and molecular weight. Results: Phenformin and glyburide were found in Tangleshu capsule, glyguanid and gliclazide were found in Ketangmin capsule. Conclusion: HPLC and LC/MS methods can be used to quantitatively determine the four above mentioned components simultaneously.

Key words: Hypoglycemic agents, Medicine, Chinese Traditional, Glyguanid, Phenformin, Gliclazide, Glyburide, Chromatography

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