Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (10): 67-73.doi: 10.6040/j.issn.1671-7554.0.2019.765

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Research progress on fertility of the Klinefelter syndrome

MA Gang, XU Chao   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250001, Shandong, China
  • Published:2022-09-27

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Abstract: The Klinefelter syndrome is the most frequent chromosomal aberration in infertile males. Due to testicular 山 东 大 学 学 报 (医 学 版)57卷10期 -马刚,等.克氏综合征的生育相关研究进展 \=-dysplasia, patients are often diagnosed with azoospermatism and cannot have offspring. Many couples choose to adopt or use donor sperms to have babies. In recent years, with the development of assisted reproductive technology, there have been more strategies for the treatment of patients with Klinefelter syndrome. Endocrine therapy and intracytoplasmic sperm injection with sperm acquired from the testicle make it possible for patients to have offspring. In this paper, we will review the research on fertility related to Klinefelter syndrome, and discuss the age of sperm extraction, surgical methods, endocrine therapy and genetic risks in patients with Klinefelter syndrome.

Key words: Klinefelter syndrome, Male infertility, Clinical manifestation, Testicular sperm extraction, Endocrine therapy

CLC Number: 

  • R574
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