JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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LIU Hua-xiang,LI Zhen-zhong,XING Yi,HUANG fei,DU fang,LIU Zhen,CHEN Shu-yan,WANG Li-hong   

  • Received:2005-11-14 Revised:1900-01-01 Online:2006-07-24 Published:2006-07-24
  • Contact: LIU Hua-xiang

Abstract: To determine the effects of human immunodeficiency virus (HIV) gp120 on dissociated cultured dorsal root ganglion(DRG) neuronal growth. Methods: Dissociated cultured rat embryo′s DRG cells were treated with HIV gp120 at different concentration (125?pmol/L, 250?pmol/L, 500?pmol/L, 1?nmol/L, respectively) and then were processed for MAP2 immunofluorescent labeling, and furthermore the changes of neuronal cell body and neurites were observed with confocal laser scanning microscope. Results: The number and length of neurites were reduced after 7day treatment with gp120 compared with control group, whereas the diameter of neuronal cell body was not obviously altered compared with control group. Conclusion: HIV gp120 may have direct influences on the outgrowth of neurites in dissociated DRG cell cultures.

Key words: HIV, Ganglion, spinal, Neurons, Confocal laser scanning microscope

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