Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (6): 41-46.doi: 10.6040/j.issn.1671-7554.0.2018.178

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Expression and clinical significance of serum lncRNA UCA1 in esophageal squamous cell carcinoma

YAN Suzhen1, DU Lutao1, WANG Lili2, WANG Chuanxin1   

  1. 1. Department of Clinical Laboratory, the Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    2. Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the expression of serum long non-coding RNA(lncRNA)urothelialcarcinoma associated 1(UCA1)in esophageal squamous cell carcinoma(ESCC)and its clinical significance. Methods A total of 96 ESCC cases and another 96 age-and gender-matched healthy controls were involved. The serum samples were collected to determine the expression of lncRNA UCA1 with qRT-PCR. The lncRNA UCA1 expression of 12 ESCC patients were compared before and after operation. The correlation between UCA1 expression and clinical pathological parameters of ESCC were analyzed, and the diagnostic value of serum lncRNA UCA1 was evaluated with the receiver operating characteristic curve(ROC). Results Compared with controls, ESCC patients had upregulated lncRNA UCA1 expression, which decreased after operation(P<0.001). In addition, the area under the curve(AUC)was 0.816, providing a sensitivity of 77.1% and a specificity of 76.0%. Moreover, lncRNA UCA1 was statistically superior to squamous cell carcinoma antigen(AUC=0.679)in discriminating ESCC patients from healthy controls(P<0.001). Conclusion Serum lncRNA UCA1 may serve as a potential tumor biomarker for the early diagnosis and postoperative monitoring of ESCC.

Key words: Esophageal squamous cell carcinoma, Long non-coding RNA UCA1, Diagnosis, Monitoring, Biomarker

CLC Number: 

  • R574
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