Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 76-80.doi: 10.6040/j.issn.1671-7554.0.2017.1020

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Clinical characteristics and influencing factors of sleep disorders in patients with Parkinsons disease

GUO Pei1,2, LI Xiuhua2, ZHANG Xiaotao1,2, HE Tianqi1,2, ZHU Meijia2, TANG Jiyou2, ZHAO Zhangning2, MAO Fei2   

  1. 1. Weifang Medical University, Weifang 261000, Shandong, China;
    2. Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To investigate the characteristics and influencing factors of sleep disorders(SD)in patients with Parkinsons disease(PD). Methods A total of 50 PD patients with SD(PD-SD group)and 50 PD patients without SD(PD-NSD group)were included, according to the diagnostic criteria of The Third Edition of the International Classification of Sleep Disorders, Parkinson Disease Sleep Scale(PDSS), Insomnia Severity Index(ISI), Epworth Sleepiness Scale(ESS)and polysomnography(PSG). The Hoehn-Yahr(H-Y)score was graded. The levels of serum high-sensitivity C-reactive protein(hs-CRP), serum iron(SI), serum ferritin(SF)and transferring(TRF)were detected and analyzed between the two groups. Results Comparied with PD-NSD group, the PDSS score, total sleep time, sleep efficiency(SE), proportion of rapid eye movement(REM)stage, non-rapid eye movement(NREM)stage 2, NREM stage 3, and SI were shorter or lower in the PD-SD group(P<0.05); the ESS score, ISI score, course of disease, total arousal time, sleep latency(SL), proportion of NREM stage 1, apnea-hypopnea index(AHI), periodic 山 东 大 学 学 报 (医 学 版)56卷4期 -郭配,等.伴有睡眠障碍帕金森病患者的睡眠特征及其影响因素 \=-limb movement index(PLMI), hs-CRP and TRF were longer or higher in the PD-SD group(P<0.05). Multiple stepwise analysis showed that the IS level influenced the PDSS and ESS scores, and the hs-CRP level influenced the ISI score. Conclusion Sleep disturbances in PD-SD patients are characterized by disordered sleep structure, decreased sleep quality, severe insomnia, daytime sleepiness, respiratory disorder during sleep, abnormal sleep behaviors and parasomnias. The sleep disorders of PD-SD patients may involve inflammatory reaction and iron metabolism disturbance.

Key words: Parkinsons disease, Sleep disorders, Polysomnography, Inflammatory reaction, Iron metabolism

CLC Number: 

  • R742.5
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