Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 64-69.doi: 10.6040/j.issn.1671-7554.0.2017.1105

Previous Articles    

Clinical treatment value of preimplantation genetic screening for unexplained repeated implantation failure

ZHANG Dandan, XIE Hongqiang, WU Qianqian, LI Hongchang, ZHU Yueting, LU Juanjuan, JIANG Wenjie, YAN Junhao   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    Key Laboratory for Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250001, Shandong, China
  • Published:2022-09-27

Abstract: Objective To evaluate the clinical results of preimplantation genetic screening(PGS)in patients with unexplained recurrent implantation failure(uRIF). Methods A total of 140 patients diagnosed as having uRIF were collected and 189 transfers after referral were analyzed(95 circles in PGS group, 94 circles in control group); 72 patients who underwent PGS were included in the PGS group, while 68 non-PGS patients were included in the control group. All the subjects were divided into two subgroups by age(<35 years, ≥35 years), and the clinical outcome were compared. Results After referral, the implantation rate(P=0.001)and clinical pregnancy rate(P=0.045)per transfer were significantly higher in the PGS group than those in the control group. There were no significant differences between the two 山 东 大 学 学 报 (医 学 版)56卷4期 -张丹丹,等.植入前遗传学筛查对不明原因反复种植失败患者的临床治疗价值 \=-groups in abortion rate, live birth rate of the first transfer, cumulative live birth and twinning rates. Among women aged ≥35 years, the implantation rate(P=0.003)and clinical pregnancy rate(P=0.027)per transfer were significantly higher in the PGS group than those in the control group, and there were no significant differences between the two groups in abortion rate, ongoing pregnancy rate, live birth rate of the first transfer and cumulative live birth(P>0.05). However, among women aged <35 years, no significant differences were found between two groups in the implantation rate, clinical pregnancy rate, ongoing pregnancy rate, abortion rate, live birth rate of the first transfer and cumulative live birth(P>0.05). Conclusion PGS can improve the implantation rate and clinical pregnancy rate among patients over 35 years old with uRIF.

Key words: Preimplantation genetic screening, Unexplained recurrent implantation failure, Implantation rate, Clinical pregnancy rate, Live birth rats

CLC Number: 

  • R714.8
[1] Calhaz C, Geyter C, Kupka MS, et al. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE[J]. Hum Reprod, 2016, 31(8): 1638-1652.
[2] Polanski LT, Baumgarten MN, Quenby S, et al. What exactly do we mean by ‘recurrent implantation failure’? A systematic review and opinion[J]. Reprod Biomed Online, 2014, 28(4): 409-423.
[3] Lee E, Illingworth P, Wilton L, et al. The clinical effectiveness of preimplantation genetic diagnosis for aneuploidy in all 24 chromosomes(PGD-A): systematic review[J]. Hum Reprod, 2015, 30(2): 473-483.
[4] Kohn TP, Kohn JR, Darilek S, et al. Genetic counseling for men with recurrent pregnancy loss or recurrent implantation failure due to abnormal sperm chromosomal aneuploidy[J]. J Assist Reprod Gen, 2016, 33(5): 571-576.
[5] Cao H, You D, Yuan M, et al. Hysteroscopy after repeated implantation failure of assisted reproductive technology: A meta-analysis[J]. J Obstet Gynaecol, 2018, 1(2): 1-9.
[6] Valdes CT, Schutt A, Simon C, et al. Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium[J]. Fertil Steril, 2017, 108(1): 15-18.
[7] Fang C, Huang R, Li TT, et al. Day-2 and day-3 sequential transfer improves pregnancy rate in patients with repeated IVF-embryo transfer failure: a retrospective case-control study[J]. Reprod Biomed Online, 2013, 26(1): 30-35.
[8] Senocak GC, Yapca OE, Borekci B, et al. Comparison of pregnancy rates between patients with and without local endometrial scratching before intrauterine insemination[J]. J Gynecol Obstet Hum Reprod, 2017, 46(9): 687-690.
[9] Zhang Q, Zhang B, Yan J, et al. Intracavitary physiotherapy is not inferior to endometrial scratching in patients with recurrent implantation failure[J]. Arch Gynecol Obstet, 2015, 291(1): 173-177.
[10] 温惠慧,纪亚忠. 粒细胞集落刺激因子免疫调节胚胎植入的研究进展[J]. 生殖医学杂志, 2017, 26(7): 730-734. WEN Huihui, JI Yazhong. Research progress in effect of granulocyte colony-stimulating factor on immune regulation in embryo implantation[J]. J Reprod Med, 2017, 26(7): 730-734.
[11] Nakagawa K, Kwak-Kim J, Ota K, et al. Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios[J]. Am J Reprod Immunol, 2015, 73(4): 353-361.
[12] Hashimoto T, Koizumi M, Doshida M, et al. Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: a retrospective, two-centers study[J]. Reprod Med Biol, 2017, 16(3): 290-296.
[13] Carballo E, Duran L, Campos JA, et al. Assisted hatching following embryo implantation failure[J]. Ginecol Obstet Mex, 2012, 80(8): 509-513.
[14] Maekawa R, Taketani T, Mihara Y, et al. Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure[J]. Reprod Med Biol, 2017, 16(2): 206-227.
[15] Majumdar G, Majumdar A, Lall M, et al. Preimplantation genetic screening for all 24 chromosomes by microarray comparative genomic hybridization significantly increases implantation rates and clinical pregnancy rates in patients undergoing in vitro fertilization with poor prognosis[J]. J Hum Reprod Sci, 2016, 9(2): 94-100.
[16] Rubio C, Rodrigo L, Mir P, et al. Use of array comparative genomic hybridization(array-CGH)for embryo assessment: clinical results[J]. Fertil Steril, 2013, 99(4): 1044-1048.
[17] Blockeel C, Schutyser V, Devos A, et al. Prospectively randomized controlled trial of PGS in IVF/ICSI patients with poor implantation[J]. Reprod Biomed Online, 2008, 17(6): 848-854.
[18] Mastenbroek S, Twisk M, Veen F, et al. Preimplantation genetic screening: a systematic review and meta-analysis of RCTs[J]. Hum Reprod Update, 2011, 17(4): 454-466.
[19] Tan JK, Tan EL, Kanagalingam D, et al. Multiple pregnancy is the leading contributor to cesarean sections in in vitro fertilization pregnancies: An analysis using the Robson 10-group classification system[J]. J Obstet Gynaecol Re, 2016, 42(9): 1141-1145.
[20] Meyer LR, Klipstein S, Hazlett WD, et al. A prospective randomized controlled trial of preimplantation genetic screening in the “good prognosis” patient[J]. Fertil Steril, 2009, 91(5): 1731-1738.
[21] Rubio C, Bellver J, Rodrigo L, et al. Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials[J]. Fertil Steril, 2013, 99(5): 1400-1407.
[22] Choi Y, Kim HR, Lim EJ, et al. Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure(RIF)[J]. PLoS One, 2016, 11(6): e0157696. doi:10.1371/journal.pone.0157696.
[23] Debrock S, Melotte C, Spiessens C, et al. Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial[J]. Fertil Steril, 2010, 93(2): 364-373. doi:10.1371/journal.pone.0157696
[24] 龙洋, 罗艳梅, 徐聚春, 等. 无创DNA检测在诊断高龄孕妇胎儿非整倍体中的应用[J]. 实用妇产科杂志, 2017, 33(5): 373-375. LONG Yang, LUO Yanmei, XU Juchun, et al. Application of non-invasive prenatal testing for fetal chromosomal aneuploidy in advanced age pregnant women[J]. J Practical Obstet Gynecol, 2017, 33(5): 373-375.
[25] Hellani A, Abu-Amero K, Azouri J, et al. Successful pregnancies after application of array-comparative genomic hybridization in PGS-aneuploidy screening[J]. Reprod Biomed Online, 2008, 17(6): 841-847.
[1] LI Yun, ZHONG Wanxia, YAO Ning, HU Shuanggang, LIU Hongmao. Effects of female age on the outcome of preimplantation genetic diagnosis and screening [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 60-62.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!