Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (3): 89-95.doi: 10.6040/j.issn.1671-7554.0.2021.1046

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Value of preoperative multiphase MRI for predicting microvascular invasion and early recurrence of 169 hepatocellular carcinoma

ZUO Liping1,2, JIANG Fengyang1,2, ZHOU Binbin1,2, FAN Jinlei1,2, LIANG Yongfeng2, DENG Zhanhao1,2, YU Dexin1,2   

  1. 1. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-03-09

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Abstract: Objective To investigate the significance of preoperative contrast-enhanced multiphase magnetic resonance imaging(MRI)in the identification of microvascular invasion and early recurrence in patients with hepatocellular carcinoma(HCC). Methods This retrospective study included 169 HCC patients treated with surgical resection during Feb. 2015 and Jan. 2019 who underwent preoperative multiphase MRI. Clinical, biologic and imaging features associated with microvascular invasion and early recurrence(within 2 years)were analyzed. MRI predictors for microvascular invasion were evaluated with univariate and multivariate Logistics analysis. Predictors of early recurrence were determined with Logistic regression and multivariate Cox analysis. Early recurrence and overall recurrence in microvascular invasion were evaluated with Kaplan-Meier analysis. Results In multivariate Logistics analysis, tumor size >5 cm(OR=7.1, 95%CI: 1.3-38.8,P=0.023), corona enhancement(OR=2.1, 95%CI: 0.8-5.5, P=0.018), and non-smooth tumor margin(OR=3.3, 95%CI: 1.0~10.5, P=0.045)were independent significant variables associated with microvascular invasion. In multivariate Cox analysis, microvascular invasion was a non-statistically significant factor(P=0.09). Kaplan-Meier curve showed that patients with microvascular invasion had lower early and overall recurrence-free survival. Conclusion Tumor size >5 cm, corona enhancement, and non-smooth tumor margin are independent predictors for microvascular invasion in HCC. Microvascular invasion is an important prognostic indicator but with a poor ability to predict early recurrence.

Key words: Hepatocellular carcinoma, Magnetic resonance imaging, Microvascular invasion, Early recurrence, Diagnosis

CLC Number: 

  • R574
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