Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (10): 96-102.doi: 10.6040/j.issn.1671-7554.0.2020.1116

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Observation value of neonatal cerebral fiber bundle and its effect on lateralization

LIU Yanyan1, FU Zhenmei1,2,3, YU Qiaowen1,2,3, SUI Yi4, CHEN Jinge1, GAO Jie1, LIN Xiangtao1,2,3, WANG Ximing1,2,3, HOU Zhongyu1,2,3   

  1. 1. Department of Imaging, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Department of Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    3. Department of Imaging, Shandong Provincial Hospital, Jinan 250012, Shandong, China;
    4. Department of Imaging, The Second Peoples Hospital of Dongying, Dongying 257000, Shandong, China
  • Published:2021-10-15

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Abstract: Objective To explore the effect of the changes of parameters of neonatal cerebral fiber bundle on the reproducibility and lateralization. Methods High angular resolution diffusion imaging(HARDI)data were obtained in 40 term infants born between 36.6 and 42.1 weeks(median 40 weeks). Multiple regions of interest(ROIs)protocol were used to describe the main brain tracks, such as cortico-spinal tract(CST), cingulum cingulate(CGC), forceps major(Fmajor)and frontal projection(Fminor)of corpus callosum, inferior longitudinal fasciculus(ILF), uncinate fasciculus(UNC)and inferior fronto-occipital fasciculus(IFO)by MRtrix3 software. Different cutoff values and angles were analyzed to evaluate the volume changes and reproducibility of tracks, and the effect on lateralization was analyzed with splicing design variance analysis. Results The volume of tracts significantly reduced if the angle was 45, while the inter-rater and intra-rater variability reduced with the consistency dispersion increased if the cutoff value was 0.02. The changes of tractography parameters affected the results of lateralization analysis. The bilateral CST, CGC and UNC showed significant lateralization. The FA values of corticospinal tract and cingulate tract showed statistically significant lateralization, which were mainly affected by changes of the cutoff and angle. Conclusion Optimal parameters of tractography will improve the reproducibility of results of fiber tracking, which is expected to be helpful to describe development of newborn white matter tracts.

Key words: Newborn, White matter bundle, Tractography, Multi-shell high angular resolution diffusion imaging

CLC Number: 

  • R722.1
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