Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (9): 97-103.doi: 10.6040/j.issn.1671-7554.0.2019.594

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MR-diffusion tensor image and diffusion kurtosis image of spatio-temporal development of new-born cerebral cortex

WANG Lifeng1, LI Zheng2, YÜ Qiaowen2   

  1. 1. Department of Obstetrics, Shandong Maternal and Child Health Hospital, Jinan 250014, Shandong, China;
    2. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the spatio-temporal development of newborn cerebral cortex by describing the changes of parameters from diffusion tensor image(DTI)and diffusion kurtosis image(DKI)with newborns with different gestational ages. Methods The T1WI and multiple-shell DWI data of brain of newborn with gestational age ranging from 36.6 to 44.4 weeks were obtained. The diffusion parameters including fractional anisotraphy(FA), mean diffusivity(MD), axial diffusivity(AD), radial diffusivity(RD)and mean kurtosis(MK)were analyzed with GBSS method. Results Dramatic decrease of FA and AD values were detected from cerebral cortex before 40 gestational weeks(frontal lobe AD: β=-0.49, P=0.01; parietal lobe FA: β=-0.48, P=0.02; parietal lobe AD: β=-0.62, P=0.003; temporal lobe FA: β=-0.44, P=0.04; temporal lobe AD: β=-0.5, P=0.01; occipital lobe FA: β=-0.53, P=0.01; occipital lobe AD: β=-0.55, P=0.009), while no significant result was found within any lobe after 40 PCW. The frontal lobe had higher developmental rate than the occipital lobe(F=9.36, P=0.004). The changes of MK values supplemented the information of cerebral cortex microstructure changes. Conclusion The differences among changes of parameters from DTI and DKI data in the time and spatial dimensions reflect the spatio-temporal development of cerebral cortex 山 东 大 学 学 报 (医 学 版)57卷9期 -王丽凤,等.足月新生儿大脑皮质时间-空间异质性发育的磁共振弥散张量及弥散峰度 \=-of newborn.

Key words: Newborn, Cerebral cortex, Spatial-temporal development, Diffusion image of multi-spherical shell

CLC Number: 

  • R742.8
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