JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (9): 60-65.doi: 10.6040/j.issn.1671-7554.0.2016.015

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Therapeutic effect of astragalus polysaccharides/chitosan microspheres on rats with allergic rhinitis

SUN Yuqing1, LI Wentao1, LIU Kang2, ZHAO Limin3, ZHANG Weifen2   

  1. 1. Clinical College, Weifang Medical University, Weifang 261053, Shandong, China;
    2. College of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China;
    3. Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong, China
  • Received:2016-01-06 Online:2017-09-10 Published:2017-09-10

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Abstract: Objective To explore the therapeutic effect of astragalus polysaccharides/chitosan microspheres on rats with allergic rhinitis. Methods Astragalus polysaccharides/chitosan microspheres were prepared with spray drying method, and the physicochemical properties of microspheres were characterized by drug loading, particle size and morphology. A total of 60 healthy Wistar rats were randomly divided into the following groups: normal group, model group, budesonide group, astragalus polysaccharides/chitosan microspheres low-dose group, moderate-dose group and high-dose group. Allergic rhinitis rat models were built by intraperitoneal injection of aluminum hydroxide gel and intranasal administration of ovalbumin. The budesonide group was given budesonide solution by continuous nasal administratio; the polysaccharides/chitosan microspheres low-dose group, moderate-dose group and high-dose group were treated with saline solution of astragalus polysaccharide/chitosan microspheres with different dosages; the model group and normal group were treated with normal saline. The effects of the drugs on syndrome scores and pathological changes were observed. Results The symptoms of allergic rhinitis and pathological changes were effectively inhibited or reduced by 山 东 大 学 学 报 (医 学 版)55卷9期 -孙玉卿,等.黄芪多糖/壳聚糖缓释微球对大鼠变应性鼻炎的治疗作用 \=-astragalus polysaccharides/chitosan microspheres. Conclusion The astragalus polysaccharides/chitosan microspheres have significant therapeutic effect on allergic rhinitis in rats.

Key words: Microspheres, Allergic rhinitis, Astragalus polysaccharides, Chitosan, Nasal administration

CLC Number: 

  • R944
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