JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (11): 82-86.doi: 10.6040/j.issn.1671-7554.0.2015.777

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Epidemiological characteristics of hemorrhagic fever with renal syndrome patients in Huangdao District of Qingdao City, China from March, 2012 to February, 2013

ZHANG Zhentang1, FANG Lizhu2, XUE Zaifeng1, ZHAO Li2, MA Dongqiang1, WEN Hongling2, LIU Jianwei2, ZHANG Xiaoshuang2, YU Xuejie2   

  1. 1. Department of Prevention and Control of Infectious Disease, Center for Disease Control and Prevention of Huangdao District, Huangdao 266400, Shandong, China;
    2. Department of Microorganism Examination, School of Public Health, Shandong University, Jinan 250012, Shandong, China
  • Received:2015-08-18 Online:2016-11-10 Published:2016-11-10

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Abstract: Objective To investigate the incidence and epidemiological feature of hemorrhagic fever with renal syndrome(HFRS)from March, 2012 to February, 2013 in Huangdao District, Qingdao City and provide the data for the prevention and control of HFRS. Methods A total of 106 acute phase sera of suspected HFRS patients were collected from Huangdao District. These samples were analyzed for Hantavirus(HV)IgM antibodies and RNA through ELISA and nested RT-PCR respectively. HV RNA positive samples were used for genotypic assay. Results Twenty sera of one hundred and six acute phase sera were positive to HV-IgM antibody, and 2 sera were positive to Hantanvirus(HTN)RNA. One of the sera is positive validated by nested RT-PCR, as well as by ELISA. So the total positive number is 21, and the total positive rate was 19.8%. Among these patients, 14 were male and 7 were female, most of whom belonged to the 45-59 year-old group. The disease had mostly occurred in autumn with 16 positive cases and there were also sporadic cases in other seasons. Five of the twenty-one sera were positive in Zangnan County from March, 2012 to February, 2013 and other counties still had some cases. Conclusion In Huangdao District of Qingdao 山 东 大 学 学 报 (医 学 版)54卷11期 -张振堂,等.2012年3月~2013年2月青岛市黄岛区肾综合征出血热流行特征 \=-City, HFRS mainly occurrs in autumn and most patients are middle-age men.

Key words: Serological test, Reverse transcription polymerase chain reaction, Hantavirus, Hemorrhagic fever with renal syndrome

CLC Number: 

  • R181.3
[1] 马超锋,余鹏博,李恒新,等.中国肾综合征出血热流行现状及免疫策略[J]. 中华预防医学杂志, 2014, 48(12):1039-1042.
[2] Fang LZ, Zhao L, Wen HL, et al. Reservoir host expansion of hantavirus, China[J]. Emerg Infect Dis, 2015, 21(1):170-171.
[3] 张云. 我国肾综合征出血热的流行病学研究现状、问题与展望[J].中国媒介生物学及控制, 2002, 13(2): 85-88.
[4] 黄立勇,周航,殷文武,等. 2010年中国肾综合征出血热监测及疫情分析[J].中华流行病杂志, 2012, 33(7): 685-691. HUANG Liyong, ZHOU Hang, YIN Wenwu, et al. The current epidemic situation and surveillance regarding hemorrhagic fever with renal syndrome in China, 2010[J]. Chin J Epidemiol, 2012, 33(7):685-691.
[5] 于式德, 孟兆海. 青岛市2007年肾综合征出血热监测分析[J].医学动物防制, 2008, 24(11):825-827. YU Shide, MENG Zhaohai. Epidemiological analysis on surveillance of hemorrhagic fever with renal syndrome in Qingdao in 2007 [J]. Chin J Pest Control, 24(11):825-827.
[6] 邱波,张名广,于式德,等. 青岛市肾综合征出血热监测点疫情流行趋势分析[J].中国媒介生物学及控制杂志, 2012, 23(5):464-466. QIU Bo, ZHANG Mingguang, YU Shide, et al. Analysis of epidemiological trends of hemorrhagic fever with renal syndrome in its present surveillance sites in Qingdao [J]. Chin J Vector Biol & Control, 2012, 23(5):464-466.
[7] 张永振,肖东楼,王玉,等. 中国肾综合征出血热流行趋势及其防制对策[J].中华流行病学, 2004, 25(6):466-469. ZHANG Yongzhen, XIAO Donglou, WANG Yu, et al. The epidemic characteristics and preventive measures of hemorrhagic fever with syndromes in China [J]. Chin J Epedemiol, 2004, 25(6):466-469.
[8] 联合国世界卫生组织. 联合国世界卫生组织对年龄的划分标准[EB/OL]. [2015-08-18]. http://wenku.baidu.com/view/723e1daf0029bd64783e2cfc.html.
[9] 吴学香,董春亮,孟兆海. 2008年胶南市肾综合症出血热流行特征分析[J].预防医学论坛, 2011, 17(5): 443-444. WU Xuexiang, DONG Chunliang, MENG Zhaohai. Epidemical analysis on HFRS in Jiaonan City, 2008[J]. Prev Med Trib, 2011, 17(5):443-444.
[10] 安丰霞, 陈东, 李欣. 浅谈胶南市2010年流行性出血热防治工作情况[J].中国农村医学杂志, 2011, 9(1): 80-82.
[11] 张云,朱进,邓小昭,等. 革螨、恙螨传播肾综合征出血热病毒的实验研究[J].中华流行病学, 2001, 22(5): 352-354. ZHANG Yun, ZHU Jin, DNEG Xiaozhao, et al. Experimental study on the roles of gasmid mite and chigger mite in the transmission of hemorrhagic fever with renal syndrome virus[J]. Chin J Eprdemiol, 2001, 22(5):352-354.
[12] 张云,朱进,邓小昭,等. 革螨及恙螨体内肾综合征出血热病毒定位的研究[J].中华预防医学杂志, 2002, 36(4):232-234. ZHANG Yun, ZHU Jin, DNEG Xiaozhao. Distribution of hemorrhagic fever with renal sysndrome virus in gamasid mites and chigger mites [J]. Chin J Prev Med, 2002, 36(4):232-234.
[13] Liu JW, Wen HL, Fang LZ, et al. Prevalence of SFTSV among Asian House Shrews and Rodents, China, January-August 2013[J]. Emerg Infect Dis, 2014, 20(12): 2126-2128.
[14] Yu XJ, Liang MF, Zhang SY, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China[J]. N Engl J Med, 2011, 364(16):1523-1532.
[15] Zhang YZ, Zhou DJ, Qin XC, et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China[J]. J Virol, 2012, 86(5): 2864-2868.
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