JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 6-10.doi: 10.6040/j.issn.1671-7554.0.2014.218

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Effects of different doses of atorvastatin on the content of TGF-β1 and cardiac structure of dilated cardiomyopathy rats

TIAN Yan1, HOU Shanrong2, LIU Jianli2, SUN Xingsheng2, HUANG Lihong1   

  1. 1. Department of Internal Medicine, Weifang Medical University, Weifang 261053, Shandong, China;
    2. Department of Cardiology, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang 261053, Shandong, China
  • Received:2014-04-14 Revised:2014-09-04 Online:2014-09-10 Published:2014-09-10
  • Contact: 侯善荣。E-mail:hhs3191@126.com E-mail:hhs3191@126.com

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Abstract: Objective To investigate effects of different doses of atorvastatin on the content of TGF-β1 and cardiac structure of dilated cardiomyopathy (DCM) rats induced by adriamycin. Methods A total of 60 senior male SD rats were randomized into control group, model group, low-dose atorvastatin group, and high-dose atorvastatin group, with 15 animals in each group. DCM models were induced by intraperitoneal injection of adriamycin[2mg/(kg·w)] for 6 weeks. The low- and high-dose atorvastatin groups received different dosages of atorvastatin injection[5 mg/(kg·d), 20 mg/(kg·d)]. The control group were given the same dose of normal saline and and lavage. After 6 weeks, echocardiography was performed to observe the pathological changes in the myocardium. The level of TGF-β1 in serum was detected with ELISA, and TGF-β1 protein expression was measured with immunhistochemistry. Results Compared with the control group, the myocardial cell morphology, fiber arrangement, inflammatory cell infiltration of the low- and high-dose atorvastatin groups were improved. The echocardiograph showed that the enlargement of left ventricular and heart function were improved. Serum TGF-β1 levels were lower in low- and high-dose atorvastatin groups (P<0.05). The expression of TGF-β1 protein in myocardium was lower in atorvastatin groups, and the decrease in the high-dose atorvastatin group was more significant. Conclusion Atorvastatin can improve cardiac structure of DCM and restrain myocardial fibrosis. Compared with small dose of atorvastatin, high dose is more effective.

Key words: Cardiac structure, Dilated cardiomyopathy, Atorvastatin, Transforming growth factor-β1

CLC Number: 

  • R574
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