Abstract:

Objective    To observe clinical efficacy of local mild hypothermia therapy and its influence on serum contents of neuron-specific enolase (NSE) and S-100 protein in patients with acute cerebral infarction. Methods     66 patients were randomly divided into the treatment group (33 cases) and the control group (33 cases). Drugs were used in both groups, and local mild hypothermia therapy only was applied to the treatment group. Nerve function deficiency was scored by the National Institutes of Health Stroke Scale(NIHSS) before and after 7d, 14d and 30d of treatment. Serum contents of NSE and S-100protein were observed 1d, 3d, 7d and 14d after stroke. Results    Nerve function deficiency scores after 14d and 30d of treatment were lower in the treatment group than those in the control group (P<0.01). Serum contents of NSE 3d, 7d and 14d after stroke(P<0.01) and S-100 protein 7d and 14d (P<0.05) after stroke were also significantly lower. Conclusion    Local mild hypothermia therapy can protect neural cells and improve the nerve function in patients with acute cerebral infarction.

Key words: Hypothermia； Brain  infarction； Phosphopyruvate hydratase; S-100 protein