JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Polypeptide extract from scorpion venom inhibits
liver metastasis in pancreatic cancer

CUI Yazhou1, JIA Qing2, WANG Zhaopeng2, WANG Zhaoxia2,
ZHANG Yueying2, ZHANG Weidong2, HAN Jinxiang1

  

  1. （1. Shandong Medicinal Biotechnology Center, Key Laboyatory for BiotechDrugs Ministry of Health,
    Key Laboratory for Modern Medicine and Technology of Shandong Province, Jinan 250062, China；
    2. Institute of Basic Medcine, Shandong Academy of Medical Science, Jinan 250062, China）
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-03-16 Published:2009-03-16
  • Contact: HAN Jinxiang

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Abstract: To explore the inhibitory effect of polypeptide extract from scorpion venom (PESV) on liver metastasis in pancreatic cancer. MethodsA subline of human pancreatic cancer cell line MIAPaCa2 (MIAPaCa23) with high liver metastasis potential was selected and injected through the tail vein to establish a pancreatic cancer model in nude mice with high liver metastasis. The capability of invasion in vitro was evaluated by a transwell chamber system. The inhibitory effects of PESV, chemotherapeutic agent gemcitabine, and angiogenesis inhibitor TNP470 on liver metastasis in the pancreatic cancer model were compared. ResultsThe capability of invasion of the MIAPaCa23 cells was significantly decreased by PESV, and liver metastasis was significantly inhibited in nude mice models (7/10) by PESV, which was similar to that in the gemcitabinetreated group (8/10) and higher than that in the TNP470treated group. ConclusionPESV, as a novel angiocytotoxic agent, has an inhibitory effect on liver metastasis in pancreatic cancer.

Key words: Pancreatic cancer, Liver,experimental, Scorpion venom, Antitumor drug, Mice,nude

CLC Number: 

  • R730.1
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