Journal of Shandong University (Health Sciences) ›› 2020, Vol. 1 ›› Issue (7): 67-71.doi: 10.6040/j.issn.1671-7554.0.2020.0486

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A retrospective analysis of risk factors of cerebral microbleeds in 101 patients with cerebral small vessel disease

XU Yuxiang1,2, LIU Yudong1,3, ZHANG Peng1,3, DUAN Ruisheng1,3   

  1. 1. Department of Neurology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250014, Shandong, China;
    2. Department of Neurology, The 5th Peoples Hospital of Jinan, Jinan 250022, Shandong, China;
    3. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China
  • Online:2020-07-20 Published:2020-07-10

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Abstract: Objective To investigate the independent risk factors of cerebral microbleeds(CMBs)in patients with cerebral small vessel disease(CSVD). Methods A total of 101 patients who met the imaging diagnostic criteria of CSVD were divided into CMBs group and non-CMBs group. The risk factors and protective factors of CMBs were identified with statistical analysis. Results Compared with non-CMBs group, CMBs group had a higher incidence of hypertension(χ2=9.879, P=0.002), higher levels of high-sensitivity C-reactive protein(hs-CRP)(t=2.294, P=0.024), homocysteine(Hcy)(t=2.193, P=0.031), cystatin C(Cys-C)(t=2.160, P=0.034)and lipoprotein a(Lpa)(t=4.247, P<0.001), but lower level of low-density lipoprotein cholesterol(LDL-c)(t=-3.342, P=0.001). Logistic regression analysis showed that hypertension(P=0.002, OR=6.706, 95%CI: 2.011-22.362), hs-CRP(P=0.049, OR=1.279, 95%CI:1.001-1.635), Lpa(P=0.001, OR=1.006, 95%CI:1.003-1.009)and LDL-c(P=0.039, OR=0.472, 95%CI: 0.232-0.963)were independently correlated with CMBs. Conclusion Hypertension, hs-CRP and Lpa are the independent risk factors of CMBs, whereas LDL-c is a protective factor.

Key words: Cerebral microbleeds, High-sensitivity C-reactive protein, Low-density lipoprotein cholesterol, Lipoprotein a

CLC Number: 

  • R743.9
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