Abstract:

 Objective To investigate whether single nucleotide polymorphisms (SNPs) and haplotypes of COX-2 gene were susceptible to atherothrombotic ischemic stroke in the Chinese Han population.  Methods In this study two variants (-1195G/A and 8473T/C) of COX-2 were examined among 626 patients with ischemic stroke and 604 control subjects. Polymorphisms were studied both individually and as haplotypes.  Results The genotype TC in 8473T/C was significantly overexpressed in patients (OR=1.329, 95%CI=1.028-1.719, adjusted for confounding factors). Further, the haplotype AC of -1195G/A and 8473T/C was significantly higher in patients than that in the control subjects. Logistic regression analysis revealed that individuals having haplotype AC had an increased possibility of ischemic stroke (OR=1.372, 95%CI=1.070-1.760, adjusted by confounding factors). Conclusion The results suggest that genotype TC of COX-2 8473T/C and haplotype AC containing -1195A and 8473C may be a crucial risk factor of genetic susceptibility to ischemic stroke in the Chinese Han population.

Key words: Genotype； Haplotypes； Inflammation； Arteriosclerosis； Brain infarction