Abstract: Objective To summarize the clinical and pathological characteristics of children with nephrotic syndrome(NS)in clinical trials of lupus nephritis(LN), analyze the treatment plan and prognosis, and provide reference for the diagnosis and treatment. Methods Clinical data of children diagnosed with NS-type LN were collected for retrospective analysis from January 1, 2009 to December 31, 2018. Results NS was found in 30 cases(28.0%)of 107 cases with LN. The ages of onset were 5-13 years, average(9.7±2.3)years. Among them, there were 6 males and 24 females with a male to female ratio of 1∶4. The most common extrarenal manifestation is anemia. Compared with non-NS-type LN patients, the proportion of acute kidney injury and hypertension was higher and the proportion of leukopenia was lower in NS-type LN patients(P<0.001;P<0.001; P=0.01). Renal biopsy showed the most common is class Ⅳ(54.5%), followed by class Ⅴ(22.7%), Ⅱ(13.6%), Ⅴ + Ⅱ(4.5%)and Ⅴ + Ⅳ(4.5%)in 22 cases. Thirty cases were given prednisone plus immunosuppressant, including intravenous methylprednisolone pulses(MMP)combined with cyclophosphamide(CTX)(63.3%), sequential usage of mycophenolate mofetil(MMF)after MMP(3.3%), only with CTX(10.0%), MMF combined with tacrolimus(6.7%), only with MMF(3.3%), and poor medication 山 东 大 学 学 报 (医 学 版)58卷2期 -阚娜娜,等.儿童肾病综合征型狼疮性肾炎30例临床、病理及近期疗效观察 \=-compliance(13.3%). After 6 months of treatment, 17 cases had complete remission, 8 cases had partial remission, 4 cases had no remission, and 1 case had died of severe pneumonia and severe sepsis. Conclusion The proportion of acute kidney injury and high blood pressure in NS-type LN patients is high than those in non-NS-type LN patients. In NS-type LN patients, the renal pathology is complex, and class Ⅳ type is the main pathological type. Among the patients with NS-type LN or pathological type of Ⅳ, MMP joint CTX is the main induction therapy, which can effectively induce remission.

Key words: Lupus nephritis, Nephrotic syndrome, Clinical, Prognosis, Children