Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (1): 91-93.doi: 10.6040/j.issn.1671-7554.0.2019.1228

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Gastric cancer complicated with mild hemophilia and postoperative hemorrhage: a report of one case

WANG Yajie1, WEN Bei2, SHI Haoyu3, SHANG Liang1, DONG Kangdi1, LI Leping1   

  1. 1. Department of Gastroenterological Surgery;
    2. Department of Pain Management;
    3. Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Objective The purpose of this paper is to explore the perioperative management of gastric cancer complicated with hemophilia. Methods The clinical characteristics, diagnosis and treatment of postoperative hemorrhage in a patient with gastric cancer and mild hemophilia A were retrospectively analyzed, and relevant literatures were reviewed. Results The patients condition was discussed by multi-disciplinary experts. Blood examination revealed decreased activity of coagulation factor Ⅷ and confirmed mild hemophilia A. The patient stopped bleeding after transfusion of recombinant coagulation factor Ⅷ. Conclusion For gastric cancer patients complicated with hemophilia, alternative therapy is very important. The first choice is recombinant FⅧ, and duration of alternative therapy should be appropriately prolonged according to the type of operation and degree of injury. Patients should be registered in the hemophilia center for long-term follow-up.

Key words: Mild hemophilia, Gastric cancer surgery, coagulation factor Ⅷ

CLC Number: 

  • R656.6
[1] Bolton-Maggs PH, Pasi KJ. Haemophilias A and B[J]. Lancet, 2003, 361(9371): 1801-1809.
[2] 中华医学会血液学分会血栓与止血学组, 中国血友病协作组. 血友病诊断与治疗中国专家共识(2017年版)[J]. 中华血液学杂志, 2017, 38(5): 364-370. Thrombosis and Hemostasis Group, Hematology Society of Chinese Medical Association, Hemophilia Treatment Center Collaborative Network of China. Consensus of Chinese experts on diagnosis and treatment of hemophilia(version 2017)[J]. Chinese Journal of Hematology, 2017, 38(5): 364-370.
[3] Wong T, Recht M. Current options and new developments in the treatment of haemophilia[J]. Drugs, 2011, 71(3): 305-320.
[4] Tanaka KA, Key NS, Levy JH. Blood coagulation: hemostasis and thrombin regulation[J]. Anesth Analg, 2009, 108(5): 1433-1446.
[5] Blanchette VS, Key NS, Ljung LR, et al. Definitions in hemophilia: communication from the SSC of the ISTH[J]. J Thromb Haemost, 2014, 12(11): 1935-1939.
[6] Nakagawa N, Fujinaga M, Chikagawa Y, et al. Mild hemophilia A diagnosed in an adult patient on the occasion of postoperative bleeding following a second knee surgery[J]. Rinsho Ketsueki, 2019, 60(5): 398-400.
[7] Kitamura T, Sato T, Ikami E, et al. A case of a patient who is diagnosed with mild acquired hemophilia a after tooth extraction died of acute subdural hematoma due to head injury[J]. Case Reports in Dentistry, 2018, 2018:1-3. doi:10.1155/2018/7185263.
[8] Ishikawa N, Furukawa K, Yokoi K, et al. Mild hemophilia a diagnosed in a 55-year-old patient after pancreatoduodenectomy for carcinoma of the papilla of vater[J]. Journal of Nippon Medical School, 2007, 74(5): 372-376.
[9] 张之南, 郝玉书, 赵永强, 等. 血液病学[M]. 2版. 北京: 人民卫生出版社, 2011: 1309-1323.
[10] Mannucci PM, Tuddenham EG. The hemophilias-from royal genes to gene therapy[J]. New England Journal of Medicine, 2001, 344(23): 1773-1779.
[11] 张威, 毛建华. 血友病A治疗研究新进展[J]. 中华血液学杂志, 2018, 39(1): 83-86. ZHANG Wei, MAO Jianhua. Advances of hemophilia A treatment[J]. Chinese Journal of Hematology, 2018, 39(1): 83-86.
[12] Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. Guidelines for the management of hemophilia[J]. Haemophilia, 2013, 19(1): e1-e47.
[13] Escobar MA, Brewer A, Caviglia H, et al. Recommendations on multidisciplinary management of elective surgery in people with haemophilia[J]. Haemophilia, 2018, 24(5): 693-702.
[14] Benson G, Auerswald G, Dolan G, et al. Diagnosis and care of patients with mild haemophilia: practical recommendations for clinical management[J]. Blood Transfus, 2018, 16(6): 535-544.
[15] 张雪芹, 程彦, 房云海, 等. 血友病A手术前漏诊16例临床分析[J]. 社区医学杂志, 2014, 12(17): 35-36. ZHANG Xueqin, CHENG Yan, FANG Yunhai, et al. Clinical analysis of 16 cases of hemophilia A missed diagnosis before operation[J]. Journal of Community Medicine, 2014, 12(17): 35-36.
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