Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (10): 18-23.doi: 10.6040/j.issn.1671-7554.0.2018.1026

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Research progress of exosomes biomarkers in tumor development

WANG Chuanxin   

  1. Department of Clinical Laboratory, The Second Hospital of Shandong University;
    Tumor Marker Detection Engineering Laboratory of Shandong Province, Jinan 250033, Shandong, China
  • Received:2018-09-04 Published:2022-09-27

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Abstract: Exosomes, a double-layer lipid inclusion with a diameter of 50-200 nm, can carry a variety of proteins, lipids and nucleic acids, playing an important role in intercellular information transfer. As a novel biomarker, exosomes has become a hot topic in clinical reasearches in recent years. Studies have found that exosomes secreted by tumor cells play an important role in the development of tumors such as tumor immunity, angiogenesis, and tumor microenvironment 山 东 大 学 学 报 (医 学 版)56卷10期 -王传新.外泌体生物标志物与肿瘤发生发展的研究进展 \=-regulation, and may become the natural carrier of drugs for tumor treatment. With the development of proteomics, genomics and other technologies, the research on the biological characteristics and functions of exosomes has been further deepened, and the extraction and detection of exosomes have been continuously improved, providing new ideas and opportunities for the clinical diagnosis and treatment of tumors.

Key words: Exosome, Tumor, Biomarker, Diagnosis, Non-coding RNA, Drug resistance

CLC Number: 

  • R574
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