Abstract: Objective To investigate the relationship between histological subclassification of cirrhosis and liver functional scores as well as FibroScan transient elastography. Methods Clinical data of 60 biopsy-proven cirrhosis cases with different severity were collected and respectively reviewed. The liver functional scores and FibroScan values were assessed. Histology of cirrhosis was blindly subclassified using the Laennec fibrosis scoring system semi-quantitatively. Results Sixty cases were classified into 3 groups: mild cirrhosis group(n=27, 45%), moderate cirrhosis group(n=21, 35%) and severe cirrhosis group(n=12, 20%). FibroScan values of mild, moderate and severe cirrhosis groups were (14.90±5.54), (25.23±10.11) and (33.99±13.55)kPa, respectively, with significant difference among the groups (P<0.05). The areas under the receiver operating characteristic (ROC) curve of FibroScan were 0.908 for moderate to severe cirrhosis, and 0.865 for severe cirrhosis. Child-Pugh scores of the three groups were 5.61±1.14, 6.05±1.21 and 5.74±0.93, respectively, with no significant difference among them (P>0.05). MELD scores of the three groups were 5.90±4.22, 7.14±5.33 and 7.03±5.13, respectively, with no significant difference (P>0.05). Conclusion FibroScan is a valuable examination for liver cirrhosis. There is no correlation between liver functional scores and histological subclassification of cirrhosis.

Key words: Child-Pugh score, Histological subclassification, FibroScan value, Liver cirrhosis, MELD score