Abstract: Objective To explore the efficacy and prognosis of tirofiban combined with intra aortic balloon pump (IABP) for patients who had complex coronary artery disease after undergoing percutaneous coronary intervention (PCI). Methods Data of 90 cases of complex coronary artery disease confirmed by coronary angiography who underwent PCI during Jan. 2011 to Dec. 2013 in our hospital were retrospectively analyzed. Patients were divided into three groups: tirofiban group (Group A), tirofiban combined with IABP group (Group B), and IABP group (Group C). The vascular lesions, postoperative cardiac function index, bleeding complications and incidence of thrombocytopenia, and incidence of heart disease 30 days after PCI were compared. Results Five days after PCI, left ventricular ejection time (LVEF) in groups B and C were higher than than that in group A (P<0.05), and the level of BNP was significantly higher in Group A than in groups B and C (P<0.05). Platelet counts showed no significant differences among the three groups (P >0.05). One patient in group B and 2 in group C developed thrombocytopenia, but 3 days after stopping using heparin and withdrawing IABP, the platelet count returned to normal. The incidence of major adverse cardiovascular events (MACE) was significantly lower in group B than in groups A and C. Conclusion During PCI, combining tirofiban and IABP early for patients who had complex lesions can significantly improve coronary blood flowand myocardial perfusion, and reduce the incidence of MACE within 30d without increasing the risk of bleeding.

Key words: Percutaneous coronary intervention, Complex coronary artery lesions, Intra aortic balloon pump, Tirofiban, Observation of curative effect