Abstract:

Objective   To explore the effect of hyperandrogenemia on lipid metabolism in patients with polycystic ovary syndrome (PCOS) in Ningxia Hui Autonomous Region. Methods    A total of 267 female patients with PCOS (178 Han and 89 Hui nationalities) were collected in this study, who were divided into high androgen group and normal androgen group according to   their blood testosterone levels. And then their clinical characteristics of hyperandrogenemia were analyzed and compared. Results   ① In all ethnic patients, in Hui and Han patients, the incidence of acne was 20.60%, 16.85% and 22.47%; the incidence of hirsutism was 25.09%, 21.35% and 26.97%; the incidence of hyperandrogenemia was 47.56%, 50.56% and 46.06%, respectively. Hirsutism was more common in Han group than in Hui group (P<0.01). ② In all ethnic patients, the total cholesterol (CHO) and apolipoprotein (ApoB) were significantly higher in the hyperandrogenemia group than in normal androgen group (P<0.05). In Han patients, CHO, low-density lipoprotein (LDL) and ApoB were significantly higher in the hyperandrogenemia group than in normal androgen group (P<0.05 or P<0.01). In Hui patients, there was no significant difference between the two groups (P>0.05). ③ In the non-obesity Han group with non-IR, CHO and ApoB were significantly higher in the hyperandrogenemia group than in normal androgen group (P<0.05). Conclusion    Hyperandrogenemia is the risk factor for dyslipidemia in women with PCOS, independent of obesity and insulin resistance. However, there exist differences between Hui and Han groups.

Key words: Polycystic ovary syndrome;  Hyperandrogenemia; Lipid metabolism; Obesity； Insulin resistance