Abstract:

Objective   To investigate the distribution and antibiotic resistance of bacteria isolated from clinical samples and to guide reasonable clinical treatment of antibiotics. Methods   3598 strains of bacteria with their drug sensitivity test results during May 2010 to Apr. 2012 were reviewed retrospectively. Results   In  3598 strains of pathogenic bacteria, 2895 (80.5%) strains were gram-negative bacilli which containedd 784( 21.9%)strains of Escherichia coli， 703(19.6%) strains of Pseudomonas aeruginosa， 462(12.8%) strains of Klebsiella pneumoniae, 399 (11.1%) strains of Acinetobacter baumannii. The positive rate of extendedspectrum β-lactamases from Escherichia coli and Klebsiella pneumoniae were 55.5% and 31.0%, respectively. Both of them were 100% sensitive to imipenem and meropenem, highly sensitive to cefoperazone/sulbactam and amikacin. The sensitivity of Escherichia coli were 99.23% and 91.96%, and the sensitivity of Klebsiella pneumoniae were 98.92% and 92.21%. The sensitivity of pseudomonas aeruginosa to cefoperazone/sulbactam，  amikacin and cefepime were 91.75%，  90.18% and 89.47%, respectively. The sensitivity of Acinetobacter baumannii to cefoperazone/sulbactam，  minocycline and ampicillin/sulbactam were 97.99%，  93.48% and 84.71%, respectively. There were 556 strains of gram-positive cocci(15.5%) which contained 139 strains of Staphylococcus aureus(3.9%)、 116 strains of coagulase-negative Staphylococci (3.2%)，  141 strains of Enterococcus faecalis (4.0%) and 101 strains of Enterococcus faecium (2.8%). The detection rate of MRSA and MRCNS were 21.6% and 56.0%, respectively. No strains of Staphylococcus and Enterococcus with resistance to vancomycin were detected.There were 147(4.1%) strains of fungi. Conclusion   To understand the distribution of pathogen bacteria and monitor its drug resistance dynamically can guide the reasonable use of antibiotics as well as control and delay the emergence of drug resistant strains.

Key words: Pathogens； Distribution； Antibiotic resistance； Antibiotics； Multidrugresistant