IgA、CD35在慢性扁桃体炎和IgAN患者扁桃体中表达的临床病理学意义

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (7): 92-95.

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Clinical and pathological significances of the expressions of IgA and CD35 in chronic tonsillitis and IgAN patients’ tonsillae

GONG Li-li1， HOU Sen2， REN Yu-bo3， LI Lian-qing1， WANG Jing1， ZHANG Ting-guo4

1. Ophthalmological and Otolaryngological Hospital, Liaocheng People′s Hospital, Liaocheng 252000, Shandong China;
2. ENT department, Yanggu People′s Hospital, Yanggu 252300, Shandong， China;
3. Department of Pathology, Liaocheng People′s Hospital, Liaocheng 252000, Shandong, China;
4. Department of Pathology, School of Medicine, Shandong University, Jinan 250012, China

Received:2013-01-14 Online:2013-07-10 Published:2013-07-10

Abstract

Abstract:

Objective To observe the expression and significance of IgA and CD35 in chronic tonsillitis and IgA-N patients, and to explore the difference of IgA and CD35 expressions in the two kinds of patients′ tonsillae. Methods Tonsillar specimens of 37 IgA-N patients and 80 chronic tonsillitis patients were examined by immunohistochemical staining with IgA and CD35. Positive staining cells were counted under the light microscope, and statistical analysis of IgA and CD35 positive staining cells was carried out by t-test. Results The expressions of IgA and CD35 in IgA-N tonsillae were strongly positive and presented positive correlation. The positive expressions of IgA and CD35 in chronic tonsillitis tonsillae significantly reduced. Conclusion There were significant differences of IgA and CD35 expressions in chronic tonsillitis and IgA-N patients. The expressions of IgA and CD35 in chronic tonsillitis may be one of the earlier period events, and can be the index for the early diagnosis of IgA-N.

Key words: IgA nephropathy; Tonsilla; IgA; CD35

CLC Number:

R365

GONG Li-li1， HOU Sen2， REN Yu-bo3， LI Lian-qing1， WANG Jing1， ZHANG Ting-guo4. Clinical and pathological significances of the expressions of IgA and CD35 in chronic tonsillitis and IgAN patients’ tonsillae[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(7): 92-95.