Abstract:

Objective   To explore the clinical manifestations and treatments of bisphosphonate-related osteonecrosis of the jaw. Methods   The clinical manifestations、 diagnostic and treatments of 53 multiple myeloma cases of bisphosphonate-related osteonecrosis of the jaw admitted to our hospital between 2005-2011 were analyzed retrospectively. Results   53 patients were all treated with antibiotics. 12 patients of them were performed with bone debridement/palliative surgeries, 12 patients were performed with bone debridement/palliative surgeries in association with ozone treatment and 14 patients were performed with ozone treatment. 26 patients were performed in association with ozone treatment，27 patients weren’t performed in association with ozone treatment.The efficient treated with antibiotics alone was 60%, the antibiotic therapy in association with surgeries was 58.4%, in association with ozone treatment was 92.3%, no ozone treatment was 59.2%. Conclusion   Antibiotics can control disease progression in BRONJ patients, the remission rate treated by antibiotics combined with surgeries is not significantly higher than that treated by antibiotics alone, and will affect the quality of life of patients. We recommend conservative treatment in BRONJ patients.In addition, ozone treatment, compared with other treatments, has significantly higher efficiency, so its clinical application is proposed.

Key words: Bisphosphonate-related osteonecrosis of the jaw; Antibiotic; Bone debridement/palliative surgeries; Ozone treatment