Abstract:

Objective   To study the effects of serum leptin level on sustained virological response(SVR) and adverse reactions in patients with chronic hepatitis B(CHB). Methods   Mild and moderate CHB patients were engaged in the study. There were three groups :the study group (n=42), the nucleoside treatment group (n=26) and the healthy control group (n=20). There were no significant differences in age, gender and body height among three groups. Results   The serum leptin levels of CHB patients were higher than healthy people. Serum leptin levels of patients in the study group decreased gradually below the baseline at week 12 and 24， then restored after drug withdraw. Patients with SVR had lower serum leptin levels(P<0.01). The serum leptin level was significantly associated with body weight changes in the study group(r=0.996, P=0.004). Conclusion   The baseline serum leptin level is associated with SVR in CHB patients and it was a predictor for SVR. The serum leptin level is significantly associated with body weight changes during α-IFN therapy.

Key words: Chronic hepatitis B； Serum； Leptin； Virological response； Body mass index