JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (9): 91-.

• Articles • Previous Articles     Next Articles

Correlation between  SATB1 and HER2 expressions and
 the tumor grade in breast cancer

WANG Jing-nan1， ZHENG Yan2， XIAO Dong-jie2， LI Jin-xing1，
DING Bu-tong2， LIU Xiang-dong3， WANG Yun-shan2,4   

  1. 1. Department of Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250013, China;
    2. Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China;
    3. Department of Laboratory, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    4. Medical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to
    Shandong University, Jinan 250013, China
  • Received:2012-02-10 Online:2012-09-10 Published:2012-09-10

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Abstract:

Objective   To test the expressions of special AT rich sequence binding protein (SATB1) and human epidermal growth factor receptor 2(HER2 ), and to investigate their relationships with the differentiation of breast carcinoma. Methods   Expressions of SATB1 and HER2 were evaluated by  immunohistochemistry method. Fluorescence in situ hybridization(FISH) was used to test the HER2 gene amplification. The association between SATB1 and HER2 expressions and their relationships with the clinicopathologic features of breast carcinoma were analyzed. Results   SATB1 and HER2 were highly expressed in breast carcinoma, and there were a significant correlation between the two(r=0.425, P＜0.05). SATB1 and HER2 expressions were related to the tumor histological grade, and the histological grade of double positive samples was higher. Co-expression of them was significantly correlated with tumor grade Ⅲ in breast cancer(r=0.472, P＜0.05).  Conclusion   SATB1 could regulate the expression of HER2, and SATB1/HER2 positive co-expression might be a poorly differentiated marker in the breast cancer.

Key words: Breast carcinoma; Special AT rich sequence binding protein; Human epidermal growth factor receptor 2; Tumor grade; Poorly differentiated; Fluorescence in situ hybridization

CLC Number: 

  • R737.9
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