Abstract:

Objective   To observe the effect of glucocorticoid and artificial liver plasma exchange in treatment of patients who had hepatargia tendency.  Methods   91 patients with hepatargia tendency were assigned into the treatment group (n=49) and the control group (n=42). Based on the natural liver protection and anti-hepatitis B virus treatment, the treatment group received glucocorticoid or glucocorticoid in combination with artificial liver plasma exchange. The control group only received natural liver protection and anti-hepatitis B virus treatment. Results   Compared with the control group, liver function and prothrombin in the treatment group was significantly improved during and after treatment. The clinical improvement rate was higher and the hepatargia incidence was lower. Conclusion   Application of glucocorticoids and artificial liver plasma exchange, which can be blocked at an early stage of chronic hepatitis B tendency to hepatargia, reduces the incidence of liver failure and mortality of chronic liver disease, and provides a clinical basis for early prevention and treatment of hepatargia.

Key words: Hepatargia tendency; Intervention in early stage; Liver, artificial; Plasma exchange; Glucocorticoid