Abstract:

 Objective   To explore the diagnosis and treatment of primary adrenal lymphoma(PAL). Methods   Two cases of PAL(males, at a mean age of 80 years) from June 2001 to January 2011 in our hospital were retrospectively analyzed. The disease, without special clinical manifestation, was found by physical examination. Tumors were located on the left adrenal gland, and averaged 5.7(5.5-6) cm in diameter. The two patients were treated with operation, one with laparoscopic surgery, and the other with routine open surgery. Results   The tumors were pathologically diagnosed as diffuse large B cell lymphoma of the left adrenal gland. After operation, they were treated with R-CHOP (rituximab+ cyclophosphamide+ doxorubicin+ vincristine+ prednisone) regime, and followed up for 6 and 20 months，respectively. Conclusions   PAL is an extremely rare malignant tumor， and usually occurs in old men without special clinical manifestation. It could be definitely diagnosed dependent on pathological examination. PAL, not sensitive to treatment, has a poor prognosis.

Key words: Adrenal neoplasm; Lymphoma; Non-Hodgkin; Pathology