Abstract:

Objective   To investigate values of interleukin-6(IL-6)and soluble E-selectin(sE-selectin) in evaluating severity and outcome of pneumonia. Methods   37 patients with severe community-acquired pneumonia (CAP), 35 patients with non-severe CAP, and 36 healthy subjects were selected as groups A, B and C. Levels of IL-6 and sE-selectin were detected by ELISA, and high sensitivity C-reactive protein (hsCRP), percentage of neutrophils(PMN%), and PaO2/FiO2 were also determined. Results   Levels of IL-6 and sE-selectin were significantly higher in group A than those in groups B and C(P<0.001), and also higher in patients with  serere CAP complicated by multiple organ dysfunction(MODS) than in patients without MODS(P<0.001). Levels of IL-6, sE-selectin, hsCRP and PMN% were all greatly decreased in patients with CAP after treatment (P<0.001).The serum level of IL-6 had positive correlations with sE-selectin, hsCRP and PMN% in patients with pneumonia (r=0.406, 0.752, 0.678, respectively; P=0.006, 0.008, 0.009, respectively），while it had a negative correlation with PaO2/FiO2（r=-0.612, P=0.007）. sE-selecttin also had positive correlation with hsCRP and PMN% (r=0.832, 0.791, respectively; P=0.009, 0.007, respectively），while it had negative correlation with PaO2/FiO2（r=-0.689,P=0.009）.Conclusion   Detection of serum IL-6 and sEselectin has good clinical values in accessing severity and outcome of pneumonia.

Key words: Interleukins; E-selectin; Pneumonia