JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2012, Vol. 50 ›› Issue (2): 74-.

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Expression of vitamin D receptor in gastric carcinoma and
normal mucosa adjacent to carcinoma

MIAO Yu-e, WANG Jue, WANG Wei-bo   

  1. Department of Oncology, Provincial Hospital Affiliated to Shandong University, Jinan  250021, China
  • Received:2011-10-25 Online:2012-02-10 Published:2012-02-10

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Abstract:

Objective   To examine the expression of vitamin D receptor (VDR) in gastric cancer and normal mucosa adjacent to cancer. Methods   VDR expression in tumor tissue and normal mucosa was detected by immunohistochemistry for 75 cases of gastric carcinoma. Results   VDR expression in gastric tumor was significantly lower than that in normal mucosa (P＜0.05). By contrary, VDR expression did not show significant correlation with gender, age, histological classification, TNM stage, or infiltration depth. Yet, a significant correlation was found between VDR expression and carcinoma differentiation status: well differentiated carcinoma had the highest level of VDR expression (P＜0.05) among all stages. Conclusions   VDR expression can be considered as a marker of gastric cancer differentiation.

Key words: Stomach neoplasms; Vitamin D receptor; Calcitriol

CLC Number: 

  • R735.2
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