Abstract:

Objective   To explore the expressions of thrombospondin-1(TSP-1), transforming growth factor-β(TGF-β), peroxisome proliferator activated receptor-γ(PPAR-γ) in glioma tissues and its correlations with tumor angiogenesis. Methods   Expressions of TSP-1, TGF-β and PPAR-γ and microvascular density(MVD) in 62 glioma cases of low and high grades were examined with SABC immunohistochemistry． Results   The  expression rates of TSP-1, TGF-β and PPAR-γ in low-grade gliomas were 78.1%, 43.7% and 93.7% respectively； the expression rates in high-grade gliomas were 46.7%, 93.3% and 40.0% respectively, the expression of  TSP-1 and PPAR-γ both had negative correlations with TGF-β(P<0.05). It was found that the MVD of low-grade gliomas(26±5.2) was significantly lower than that of high-grade gliomas( 41±7.3)(P<0.05). TSP-1 and PPAR-γ had  negative correlations with MVD(P<0.05)， TGF-β had a positive correlation with MVD (P<0.05). Conclusion   The expression levels of TSP-1, TGF-β and PPAR-γ are correlationed with glioma MVD and and these factors may be involved in glioma angiogenesis.

Key words: Thrombospondin-1； Transforming Growth Factor -β； Peroxisome Proliferator Activated Receptor-γ； Microvascular density； Glioma