Abstract:

 Objective   To evaluate the therapeutic effect of 125Iodine seeds on the rabbit VX2 model and to examine changes in tissues of hepatoma and normal liver.  Methods   Twelve VX2 model animals made from  New Zealand rabbits were divided into two groups，a therapy group and a control group. 125Iodine seeds and dummy seeds were implanted into the tumors. CT-enhanced scanning and hepatic function examination were performed before the implantation and at 7, 14, 28 and 60 d after implantation. Pathological study of tumor and normal liver was done to evaluate the damage caused by 125I seeds.  Results   The tumors  in the therapy group were smaller than in the control group at 7, 14, 28, and 60 d after implantation. In the therapy group, the ALT value was decreased  after 14 d, and the AST value was decreased  after 7 and 14 d after implantation, as compared to those in the control group. Radiation injury was not detected with CT  in the therapy group over the period of 60 d. Conclusion   Brachytherapy with 125I seeds can significantly inhibit tumor growth while retaining  liver function; hence it is a safe and effective technique.

Key words: Hepatoma； Iodine radioisotopes； Brachytherapy； VX2 carcinoma125I